Abstract:
ABSTRACT
The purpose of this study was to evaluate the regeneration potential of decellularized bovine pericardium
grafts used as an option to close the abdominal wall defects in the experimental model.
The study group consisted of pigs subjected to reconstructive surgery of congenital abdominal wall
defects (group 1 - 3 animals) (fig. 1) and total defect of the abdominal wall created surgically (involving all
layers, including the peritoneum) with decellularized bovine pericardium (group 2 - 3 animals). Animals were
sacrificed and investigated 30 days (3 animals) and 90 days after surgery (3 animals).
he results of this experimental study have allowed us to conclude the following:
- The acellular bovine pericardium graft is characterized by strength and durability, favorable for the reconstruction
of major abdominal wall defects.
- In the regenerative-reparative processes of the acellular bovine pericardium grafts used in the reconstruction
of the abdominal wall defects together with fibrogenesis processes, there are also processes
of metaplasia with differentiation in chondroblasts which induce the neoformation of cartilage foci in
the biological implant, which, then functions as an enchondral ossification factor with the formation of
trabecular osteogenesis and ossification foci.
- The results obtained imply the need for further studies to clarify the role of these changes in the development
of potential follow-up postoperative complications.
Description:
Public Institution State University of Medicine and Pharmacy “Nicolae Testemiţanu”,
PMSI Mother and Child Institute, Chisinau, Republic of Moldova
