Department of Respiratory Medicine, State University' of Medicine and Pharmacy “Nicolae Testemitanu ”, Chisinau, Moldova, ERS National Delegate for Moldova, GOLD National Leader for Moldova, Republic of Moldova Department of Respiratory Diseases, Department of Medical and Surgical Sciences for Children & Adults, University; of Modena and Reggio Emilia, Modena, Italy Ain tree University Hospitals NHS Trust, UK University’ General Hospital, Dept, of Thoracic Medicine, 71110 Heraklion, Greece.