INFLUENCE OF COPTISINE BISULFATE ON THE EVOLUTION OF ACUTE TOXIC HEPATITIS

Peredelcu, Rodica; Gonciar, Veaceslav; Scutari, Corina; Cazacu, Vasile

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dc.contributor.author	Peredelcu, Rodica
dc.contributor.author	Gonciar, Veaceslav
dc.contributor.author	Scutari, Corina
dc.contributor.author	Cazacu, Vasile
dc.date.accessioned	2020-03-26T15:51:09Z
dc.date.available	2020-03-26T15:51:09Z
dc.date.issued	2018
dc.identifier.citation	: Peredelcu Rodica, Gonciar Veaceslav, Scutari Corina, Cazacu Vasile. (2018) The Influence of Coptisine Bisulfate on the Evolution of Acute Toxic Hepatitis. World Science. 8(36), Vol.2. doi: 10.31435/rsglobal_ws/30082018/6065	en_US
dc.identifier.issn	2413-1032
dc.identifier.issn	e-ISSN — 2414-6404
dc.identifier.uri	DOI: https://doi.org/10.31435/rsglobal_ws/30082018/6065
dc.identifier.uri	http://archive.ws-conference.com/the-influence-of-coptisine-bisulfate-on-the-evolution-of-acute-toxic-hepatitis/
dc.identifier.uri	http://repository.usmf.md/handle/20.500.12710/8156
dc.description	Republic of Moldova, Chisinau, Departement of Pharmacology and Clinical Pharmacy of SUMPh Nicolae Testemitanu	en_US
dc.description.abstract	In the experiments made on white rats was studied the influence of coptisine bisulfate, alkaloid extracted from Chelidonium majus, in the following doses: 10 mg/kg and 20 mg/kg on acute toxic hepatitis cause by carbon tetrachloride. It was established that the researched substance reduced hepatic cytolysis and cholestasis through reestablishment of the transaminases activity and lactate dehydrogenase, while lowering the alkaline phosphatase/alanine aminotransferase ratio and modulated the deflection of the metabolic parameters of acute toxic hepatitis. Coptisine bisulfate corrected the carbon tetrachloride caused hypoproteinemia when administered for 7 days and normalized the albumin level at 14th day of treatment of acute toxic hepatitis.	en_US
dc.language.iso	en	en_US
dc.publisher	The Archive of RS Global Publishing	en_US
dc.subject	coptisine bisulfate	en_US
dc.subject	toxic hepatitis	en_US
dc.subject	alanine aminotransferase	en_US
dc.subject	aspartate aminotransferaze	en_US
dc.subject	cytolysis	en_US
dc.subject	cholestasis	en_US
dc.subject	liver	en_US
dc.title	INFLUENCE OF COPTISINE BISULFATE ON THE EVOLUTION OF ACUTE TOXIC HEPATITIS	en_US
dc.type	Article	en_US