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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/7980
Title: Оптимизация фармакотерапии хронической сердечной недостаточности
Other Titles: Optimization of pharmacotherapy of chronic heart insufficiency
Optimizarea farmacoterapiei insuficienţei cardiace cronice
Authors: Тофан, Е.
Keywords: chronic heart insufficiency;drug therapy
Issue Date: 2009
Publisher: The Scientific Medical Association of the Republic of Moldova
Citation: ТОФАН, Е. Оптимизация фармакотерапии хронической сердечной недостаточности. In: Curierul Medical. 2009, nr. 6(312), pp. 11-15. ISSN 1875-0666.
Abstract: The author examined the effects of different combinations of modern drugs on the clinical symptoms of chronic heart insufficiency (CHI) and the consequent hemodynamics, morpho-functional heart parameters and the patients’ tolerance of physical effort. The study group consisted of 80 patients with chronic heart insufficiency of the II-IV functional classes (FC) and an ejection fraction of the left ventricle (LV) of less than 45%. Through two-drug therapy the mean FC of the CHI decreased 12% after 48 weeks of continuous treatment and with three-drug therapy in patients with CHI of III-IV FC the FC decreased by 20%. The combined therapy that included iATE or ARA-II and diuretics in patients with CHI of II-III FC reduced the parameters of the LV and increased the ejection fraction (EF) by approximately 10%. Also, patients receiving the tree-drug therapy decreased the parameters of the LV and increased the EF by approximately 18%.
La 80 de pacienţi cu insuficienţă cardiacă cronică (ICC), clasă funcţională (CF) II-IV şi fracţia de ejecţie (FE) a ventriculului stâng (VS) mai mică de 45%, s-a studiat efectul diferitelor combinaţii de preparate medicamentoase asupra manifestărilor clinice, hemodinamicii, parametrilor morfo-funcţionali ai cordului şi toleranţa la efort fizic. A fost stabilit că la sfârşitul celei de-a 48 săptămâni de tratament continuu, pe fundalul terapiei bicomponente, indicele mediu al CF a ICC s-a diminuat în medie cu 12%. La bolnavii cu ICC CF III-IV, care au făcut terapie tricomponentă, acest indice s-a diminuat cu 20%. Terapia combinată, care includea IECA sau ARA-II şi diuretice, administrată pacienţilor cu ICC CF II-III, a dus la micşorarea parametrilor VS şi creşterii FE cu aproximativ 10%. La bolnavii care au urmat medicaţie tricomponentă, de asemenea, s-au micşorat dimensiunile VS şi, totodată, FE a crescut în medie cu 18%.
metadata.dc.relation.ispartof: Curierul Medical
URI: http://moldmedjournal.md/wp-content/uploads/2016/09/64.pdf
http://repository.usmf.md/handle/20.500.12710/7980
ISSN: 1875-0666
Appears in Collections:Curierul Medical, 2009, Vol. 312, Nr. 6

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