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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/10199
Title: Enzimele microsomale la pacienţii cu hepatite cronice virale B şi C
Other Titles: Microsomal enzymes in patients with chronic viral hepatitis B and C
Authors: Taran, Natalia
Issue Date: 2009
Publisher: Asociaţia chirurgilor “Nicolae Anestiadi” din Republica Moldova
Citation: TARAN, Natalia. Enzimele microsomale la pacienţii cu hepatite cronice virale B şi C. In: Arta Medica. 2009, nr. 5(38), pp. 10-14. ISSN 1810-1852.
Abstract: Orice proces patologic implică decompensarea sistemelor de protecţie şi reglare a organismului, în rezultatul căruia are loc perturbarea metabolismului intracelular Ficatul se consideră filtrul biologic în administrarea toxinelor exogene în circulaţia sanguină a organismului. Studiul a cuprins 105 pacienţi cu hepatite cronice virale B şi C. La pacienţii respectivi s-au studiat marcherii de detoxicare hepatică (citocromul P450, glutation S-transferaza). Cu scop de evaluare a enzimelor microsomale pacienţii au fost cercetaţi în dependenţă de activitatea procesului inflamator hepatic şi faza infecţiei virale. Activitatea sistemului monooxigenazic este modificată în hepatitele cronice virale. Concomitent cu pătrunderea în organism a xenobioticelor, are loc inducţia sistemelor monooxigenazice cu mărirea concentraţiei citocromului P450 în hepatocite şi creşterea activităţii reacţiilor enzimatice. În hepatitele cronice virale, independent de activitatea procesului inflamator hepatic şi infecţiei virale, s-a stabilit o majorare a concentraţiei citocromului P450 şi diminuare al nivelului GStot faţă de indicii similari a persoanelor lotului martor. Studiul prezentat a constatat o diminuare al GSTtot la toţi pacienţii examinaţi din cauza dereglărilor metabolice în ficat, legate de funcţia de detoxificare a acestuia şi perturbărilor sistemului antioxidant de protecţie. Hepatitele cronice virale sunt caracterizate printr-o concentraţie sporită a citocromului P450, fapt explicat printr-o reacţie compensatorie la răspunsul acţiunii factorilor toxici şi procesului inflamator persistent.
Every pathological process implies decompensation of protective and regulatory systems of the organism, in result takes place the perturbation of intracellular metabolism. Liver is considered the biological filter in the administration of exogenous toxins in sanguine circulation of the organism. The study included 105 patients with chronic viral hepatitis B and C. In the following patients were studied the markers of hepatic detoxification ( Cytochrome P450, glutathione S-transpherase ). Patients were researched in dependence on the activity of hepatic inflammatory process and viral infection phase with the aim of microsomal enzymes evaluation. The activity of the monooxigenazic system is modified in chronic viral hepatitis. Concomitantly with the penetration of xenobiotics in organism, takes place the induction of monooxigenazic systems with the increment of Cytochrome P450 concentration in hepatocyte and the increase of the activity of enzymatic reactions. In chronic viral hepatitis, irrespective of the activity of hepatic inflammatory process and viral infection, has been established an increase of Cytochrome P450 concentration and a decrease of the GSTtot level in comparison with the similar signs of the healthy persons. The presented study showed a diminished concentration of GSTtot in all examined patients due to the metabolic disorders in liver related to its detoxification function and perturbations of the antioxidant protective system. Chronic viral hepatitis is characterized by an increased Cytochrome P450 concentration, fact which is explained by the compensatory reaction to the answer of the toxic factors as well as persistent inflammatory process action.
URI: http://repository.usmf.md/handle/20.500.12710/10199
ISSN: 1810-1852
Appears in Collections:Arta Medica Vol. 38 No 5, 2009

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