Chronic myeloid leukemia associated with early lymphoblastic crisis

Abstract

Background. The blastic crisis of chronic myeloid leukemia (CML-BC) is usually the final phase of the disease, in which the percentage of the young, often undifferentiated cells, known as blastocytes gets above 20%. Nowadays, in the era of the therapy with Tyrosine Kinase Inhibitors, the transformation from CML to CML-BC occurs much later and more rarely.