Consecinţele timpurii ale miopatiilor inflamatorii idiopatice

Abstract

Idiopathic inflammatory myopathies (IIM) are a group of rare diseases characterized by asthenia of skeletal muscles. Early approach to disease leads to a favorable evolution of the disease and less outcomes. The aim of this study is to assess the short-term outcomes in patients with IIM. We conducted a transversal study enrolling 12 patients (7 women, 5 men) with IIM, the mean age was 54.1±12.1 (30–67) years and the follow–up period was 16±9.4, (7-25) months. Patients were assessed by aplying specific questionnaires and modern, validated clinical tools.We found in all patients muscle damage manifested by muscular dysfunction – 11 (91.7%) patients and atrophy in one (8,3%) patient, confirmed by moderate muscle strengh, which implies disability – 10 (83.3%) patients. Gastrointestinal damage was manifested by dysphagia in 3 (25.0%) patients, hepatic steatosis – 3 (25.0%), dismotility – 5 (41.7%) patients. Endocrine damage like dyslipidemia had 4 (33.3%), secondary amenorrhea – 4 (33.3%), diabetes mellitus in 2 (16.6%) patients. Despite moderate disease activity the most common disease outcomes obtained were muscular – 100% patients, gastrointestinal – 91.7% and endocrine – 83.3% patients.