|
- IRMS - Nicolae Testemitanu SUMPh
- 1. COLECȚIA INSTITUȚIONALĂ
- MedEspera: International Medical Congress for Students and Young Doctors
- MedEspera 2012
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/20192
Title: | The determination of the melatonin receptors expression (MT-1, MT-2) in a stomach and duodenal mucous membrane as a way to predict the pylorobulbar ulcers activity |
Authors: | Gryazev, A. Presnov, R. |
Keywords: | melatonin;pylorobulbar ulcers |
Issue Date: | 2012 |
Publisher: | State Medical and Pharmaceutical University Nicolae Testemitanu, Medical Students and Residents Association, Scientific Association of Students and Young Doctors |
Citation: | GRYAZEV, A., PRESNOV, R. The determination of the melatonin receptors expression (MT-1, MT-2) in a stomach and duodenal mucous membrane as a way to predict the pylorobulbar ulcers activity. In: MedEspera: the 4th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2012, pp. 40-41. |
Abstract: | Introduction: In spite of all prognoses by the late 1980 s the revision of the medicamental treatment
principles didn’t lead to expecting complication rate decreasing.
Furthermore, over the last 10 years the number of patients with stomach and duodenal ulcers, which
enter the hospitals in Russia because of ulcer perforation, increased in 2,7 times and the number of ulcer
bleeding patients - in 2,2 times.
All this evidences point out the necessity to determine new factors of the ulcer pathogenesis and to
hnd new mechanisms of the ulcer formation.
Subject to melatonin properties at the level of the whole body (biorhythm, antioxidant, immunomodulatory effect) and also at the level of the digestive system (participation of the motor activity, microcirculation and proliferation); it’s easy to see, that a melatonin plays a great part in pathogenic mechanisms
of the ulcer formation and exacerbation. Recently the papers, pointing to receptor-mediated mechanism
of the melatonin anti-inflammatory effect, appeared.
Aim: This study’s aim is to determine connection between receptor expression to melatonin (MT-1,
MT-2) and probable ulcer complication prognosis.
Materials and methods: Our research consists of two parts. In experimental one we got primary
specific antibodies to MT-1, MT-2. The peptide, duplicating amino-acid sequence of active MT-1, MT-2
receptor centers, was synthesized in Research institute of particularlycleanbiological preparation.
In clinical part we exposed stomach and duodenal mucous membrane cells with MT-1, MT-2 receptors by indirect immunofluorescence. 35 patients were researched, they divided into few groups: uncomplicated ulcer - 16 patients, ulcer with perforation - 6, ulcer with bleeding - 5, control group - 8.
Results: In uncomplicated ulcer group there were 7% MT-1 and 6,5% MT-2 melatonin receptors,
in ulcer perforation group: 9,56% MT-1 and 2,53% MT-2; in ulcerbleeding group - 10,56% MT-1 and
1,46% MT-2; incontrol group - 16% MT-1 and 14,7% MT-2. After carefully examination of the groups
with complications it was founded, that 85% patient has a similar melatonin receptor distribution (the
receptor number decreased and decreasing MT-2 relative to MT-1 - 4 times).
It was exposed 4 patients in group without complications, which can be in a complication group according to results. We can suppose that they are in a risk group of the ulcer complications and they need
more careful control and perspective researching.
Conclusions:
• Patients with any ulcer defect have depressed level of the melatonin receptors. • There is decrease of MT-2 receptors relative to MT-1 in 4 times in group of patients with ulcer
complication. It can be used in complication prediction.
• Probably, the duration of ulcer case history influences the melatonin receptor expression, but we
need additional study and general sampling to prove this. |
metadata.dc.relation.ispartof: | MedEspera: The 4th International Medical Congress for Students and Young Doctors, May 17-19, 2012, Chisinau, Republic of Moldova |
URI: | http://repository.usmf.md/handle/20.500.12710/20192 |
Appears in Collections: | MedEspera 2012
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|