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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/2517
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dc.contributor.authorMoşin, Veaceslav
dc.contributor.authorVisternicean, Elena
dc.contributor.authorHotineanu, Alina
dc.contributor.authorCreţu, Adrian
dc.date.accessioned2019-06-24T20:16:05Z-
dc.date.available2019-06-24T20:16:05Z-
dc.date.issued2017
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/2517-
dc.descriptionUniversitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” Catedra Obstetrică şi Ginecologie Nr. 2 (Şef catedră, profesor universitar, d. h. ş. m. – Cerneţchi Olga) Centrul medical „Repromed”en_US
dc.description.abstractIntroduction. Elevated total serum homocysteine concentration is known to be related to many adverse pregnancy outcomes including birth defects, preeclampsia, placental abruption, spontaneous abortion, low birth weight and other maternal or fetal complications. Homocysteine is influenced by the status of B vitamins and nutritional adequacy of these vitamins is essential to maintain the plasma homocysteine levels within a normal homeostatic range. In addition, genetic polymorphism of the enzyme methylenetetrahydrofolate reductase (MTHFR), which catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate (5,10-MTHF) to 5-MTHF in the folate cycle, is known to influence homocysteine metabolism resulting in hyperhomocysteinemia. Objective: The purpose of this study was to investigate the effect of the interaction between the C677T mutation in the MTHFR genotypes and serum levels of vitamin B12 and folic acid on serum homocysteine levels in women with recurrent miscarriages. Introduction. Elevated total serum homocysteine concentration is known to be related to many adverse pregnancy outcomes including birth defects, preeclampsia, placental abruption, spontaneous abortion, low birth weight and other maternal or fetal complications. Homocysteine is influenced by the status of B vitamins and nutritional adequacy of these vitamins is essential to maintain the plasma homocysteine levels within a normal homeostatic range. In addition, genetic polymorphism of the enzyme methylenetetrahydrofolate reductase (MTHFR), which catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate (5,10-MTHF) to 5-MTHF in the folate cycle, is known to influence homocysteine metabolism resulting in hyperhomocysteinemia. Objective: The purpose of this study was to investigate the effect of the interaction between the C677T mutation in the MTHFR genotypes and serum levels of vitamin B12 and folic acid on serum homocysteine levels in women with recurrent miscarriages. Введение. Увеличение концентрации гомоцистеина в сыворотке крови связанно с повышенным риском различных осложнений беременности: репродуктивными потерями, преждевременная отслойка нормально расположенной плаценты, выраженной задержкой роста плода, ранним началом преэклампсии тяжелой степени. Уровень гомоцистеина в плазме крови зависит от уровней в крови витаминов группы В и диетологическая адекватность данных витаминов имеет важное значение для поддержания уровней гомоцистеина в плазме в пределах нормального гомеостатического диапазона. Кроме того, генетический полиморфизм фермента метилентетрагидрофолатредуктазы (MTHFR), играющего ключевую роль в метаболизме фолиевой кислоты который катализирует необоатимое изменение 5,10-метилентетрагидрофолята (5,10-MTHF) в 5-метилтетрагидрофолят (5-MTHF), одна из важных причин накопления гомоцистеина в крови. Цель: В этом исследовании, мы стремились обнаружить эффект влияния полиморфизма MTHFR С677Т, сывороточных уровней витамина В12 и фолиевой кислоты на концентрации гомоцистеина в плазме крови у женщин с привычным невынашиванием беременности.en_US
dc.language.isoroen_US
dc.subjecthomocysteineen_US
dc.subjectMTHFRen_US
dc.subjectrecurrent miscarriageen_US
dc.subjectfolateen_US
dc.subjectvitamin B12en_US
dc.titleImplicaţiile homocisteinei, vitaminelor grupului B şi polimorfismul MTHFR C677T în avortul spontan recurenten_US
dc.title.alternativeImplications of the MTHFR C677T polymorphism, homocysteine and serum B vitamins in the recurrent miscarriagesen_US
dc.typePreprinten_US
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