Lymphocytic immuno-inflammatory status in patients with parasitic arthritis depending on the etiological agent

Abstract

Summary. Objectives. Most authors attest that parasitic arthritis manifests itself immunologically in a non-specific way and, until now, the most important reactions remain unclear. The objective of our study was to evaluate the indices of cellular immunity specifically in patients with parasitic arthritis in the case of various infestation agents. Material and methods. In the study were included 161 patients, that were divided into 3 groups: first group (97 patients) with parasitic arthritis with echinococcosis infestation, the 2nd group (31 patients) – with parasitic arthritis with Toxocara cannis and the 3rd group (33 patients) – with parasitic arthritis with Giardia lamblia infestation. Results. Within the framework of the development of parasitic arthritis, the most significant changes occur in the immune status of the patients, with Giardia lamblia parasitic arthritis, followed by those with echinococcosis infestation parasitic arthritis and Toxocara cannis parasitic arthritic, which were characterized by a marked increase in CD2 cytotoxic lymphocytes and a decrease in the number of CD4 and CD8 lymphocytes, against the background of the physiological constant number of CD3 lymphocytes. Conclusions. Cellular immune status in parasitic arthritis is characterized by a deficit of control over the work of the system, expressed by a decrease in CD4 and CD8, against the background of the optimal concentration of CD3, but with increased cytotoxicity activity by increasing CD2.