The use of magnesium salts in the therapy of arterial hypertension

Abstract

Introduction. Annually, more than 10 million lives are lost due to high blood pressure (HT). A low magnesium content in drinking water leads to increased risk of developing cardiovascular disease (especially coronary heart disease) and sudden death. Magnesium (Mg2+ ) plays a direct role in the functioning of the endothelial system, controls the contraction-relaxation processes of smooth muscle cells, affects the mechanisms of vascular wall calcification, the coagulation system, systemic inflammation, as well as the conduction system of the heart. Aim of study. The research aims to analyze the bibliographic data regarding the benefits of Mg2+ salts in HT therapy. Methods and materials. To carry out the study, 21 scientific articles were researched using the following databases: PubMed, MEDLINE, SciSearch, The Thomson Corporation and Cochrane Electronic Library, Google Academic. Results. Mg2+ deficiency has been shown to correlate with a number of chronic cardiovascular diseases, including HT, diabetes mellitus, and hyperlipidemia in many studies. Unfortunately, it is impossible to ensure such an increased intake of Mg2+ only by changing the diet. For the longterm treatment of hypomagnesemia, drugs containing Mg2+ are used: tablets or oral solution. Thus, the drugs, containing inorganic salts of Mg2+, have absorption of no more than 5%, therefore, to increase bioavailability, Mg2+-salts are used in combination with vit.B6, with potassium and organic ones: aspartic acid, lactic acid, glutamic acid, citric acid, orotic acid. In case of Mg2+ deficiency, its additional administration is necessary (10-30 mg/kg per day). Depending on the clinical situation, 25% magnesium sulfate injection is given intravenously slowly in the health-care setting. Conclusion. Magnesium is an essential electrolyte for living organisms. Magnesium has vasodilatory, anti-inflammatory, anti-ischemic and antiarrhythmic properties. Mg2+ supplementation may help reduce cardiovascular risk factors associated with HT caused by Mg2+ deficiency due to chronic diuretic use, inadequate intake, or both. low magnesium content in drinking water leads to increased r isk of developing cardiovascular disease (especially coronary heart disease) and sudden deat h. Magnesium (Mg2+ ) plays a direct role in the functioning of the endothelial system, control s the contraction-relaxation processes of smooth muscle cells, affects the mechanisms of vascula r wall calcification, the coagulation system, systemic inflammation, as well as the conduction system of the heart. Aim of study. The research aims to analyze the bibliographic data regardi ng the benefits of Mg2+ salts in HT therapy. Methods and materials. To carry out the study, 21 scientific articles were res earched using the following databases: PubMed, MEDLINE, SciSearch, The Thomso n Corporation and Cochrane Electronic Library, Google Academic. Results. Mg2+ deficiency has been shown to correlate with a number of chronic cardiovascular diseases, including HT, diabetes mellitus, and hyperlipidemia i n many studies. Unfortunately, it is impossible to ensure such an increased intake of Mg2+ only by c hanging the diet. For the longterm treatment of hypomagnesemia, drugs containing Mg2+ are use d: tablets or oral solution. Thus, the drugs, containing inorganic salts of Mg2+, have absor ption of no more than 5%, therefore, to increase bioavailability, Mg2+-salts are used in combination with vit.B6, with potassium and organic ones: aspartic acid, lactic acid, gluta mic acid, citric acid, orotic acid. In case of Mg2+ deficiency, its additional administration is neces sary (10-30 mg/kg per day). Depending on the clinical situation, 25% magnesium sulfate inject ion is given intravenously slowly in the health-care setting. Conclusion. Magnesium is an essential electrolyte for living organi sms. Magnesium has vasodilatory, anti-inflammatory, anti-ischemic and antia rrhythmic properties. Mg2+ supplementation may help reduce cardiovascular risk facto rs associated with HT caused by Mg2+ deficiency due to chronic diuretic use, inadequate intake, or both.