- IRMS - Nicolae Testemitanu SUMPh
- REVISTE MEDICALE NEINSTITUȚIONALE
- The Moldovan Medical Journal
- The Moldovan Medical Journal
- The Moldovan Medical Journal 2019
- The Moldovan Medical Journal, Vol. 62, No 4, December 2019
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/7584
Title: | Haemostatic system changes during pregnancy and puerperium |
Authors: | Profire, Liliana |
Keywords: | haemostatic system;pregnancy;puerperium |
Issue Date: | 2019 |
Publisher: | The Scientific Medical Association of the Republic of Moldova |
Citation: | PROFIRE, Liliana. Haemostatic system changes during pregnancy and puerperium. In: The Moldovan Medical Journal. 2019, vol. 62, no 4, pp. 56-60. ISSN 2537-6373. DOI: 10.5281/zenodo.3556508 |
Abstract: | Background: The activity in the hemostasis system is determined by two opposite processes that function simultaneously – blood clotting (fibrin clot
formation) and fibrinolysis (the process of fibrin clot breakage). A normal balance between the processes of coagulation and fibrinolysis produces
neither coagulation nor lysis, and vice versa, the imbalance of these processes is potentially dangerous in the development of coagulopathic or lytic
events. Both systems (coagulation and fibrinolysis) undergo substantial changes in the physiological pregnancy, changes in an increase of coagulation
factors concomitant with a decrease of anticoagulants and suppression in the fibrinolysis system. The predominance of prothrombotic activity gives
the pregnancy a hypercoagulable status, with an increased risk of intravascular thrombi formation and thromboembolic complications (e.g. venous
thrombosis, DIC syndrome). On the other hand, physiological hypercoagulation during pregnancy contributes to preventing the loss of blood during
the immediate postpartum period by providing hemostasis in placental wounds and birth pathways.
Conclusions: The hemostasis system in pregnant women is marked by an increase in coagulation at each stage (from endothelium to circulatory factors
of coagulation) which presumes the risk of thrombo-embolic complications, and the inhibition in the fibrinolytic system prevents peripartum bleeding. |
metadata.dc.relation.ispartof: | The Moldovan Medical Journal |
URI: | http://repository.usmf.md/handle/20.500.12710/7584 https://doi.org/10.5281/zenodo.3556508 http://moldmedjournal.md/wp-content/uploads/2019/12/62-4-0-Moldovan-Med-J-2019-Vol-62-No-4-2.pdf |
ISSN: | 2537-6373 2537-6381 |
Appears in Collections: | The Moldovan Medical Journal, Vol. 62, No 4, December 2019
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