USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/13164
Title: Immunomodulation after ischemic stroke. Mechanisms and therapeutic implications
Authors: Glavan, Danu
Gasnaș, Alexandru
Groppa, Stanislav
Keywords: ischemic stroke;immunity;immunomodulation;inflammation
Issue Date: Oct-2020
Publisher: Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu"
Abstract: Introduction Inflammation of brain tissue after ischemic stroke leads to local and systemic effects. Immunity suppression by the nervous system results in the protection of nerve tissue from subsequent inflammatory damage. At the same time, it increases the susceptibility of the whole body to infections. Purpose Description of local and systemic immune changes that occur after an ischemic stroke, outlining the mechanisms of immunosuppression induced by cerebral ischemia and the potential therapeutic implications of these phenomena. Material and methods Articles in English were searched on the PubMed Central and Google Scholar, using the keywords “ischemic stroke”, “inflammation”, “infection”, “immunomodulation”, “immunity” and “autoimmunity”. Representative papers were selected that provided data on pathogenetic pathways and inflammatory markers in ischemic stroke and their possible therapeutic approaches. Results Inflammatory mechanisms are currently considered as an important target for stroke therapy. There is evidence that immune signals and mediators can have both detrimental and beneficial effects in particular stages of the disease process. As an ischemic stroke occurs, an inflammatory cascade is triggered with cellular elements: neutrophils, microglia, monocytes/macrophages, T and B lymphocytes and humoral ones: cytokines, free radicals, damage-associated molecular pattern, autoantibodies, etc. These may be diagnostic and prognostic factors in ischemic stroke, as well as potential therapeutic targets for the control of ischemic injury and possible complications. Currently, the target of immunomodulation translated into clinical trials is focused on the early phase of toxic neuroinflammation. However, the neuroinflammatory reaction after acute brain injury continues for months. One of the studied therapies, Fingolimod, a sphingosine-1-phosphate receptor modulator, which inhibits T lymphocytes, is shown to be promising by reducing the volume of infarction, the risk of hemorrhagic transformation and disability in Asians. There is increasing evidence that dysregulation of the immune response after the stroke might be an important predisposing factor for infection. Conclusions Evidence suggests that post-ischemic oxidative stress and inflammation contribute to brain injury and to the expansion of the ischemic lesion. On the other hand, an adequate adaptive immune response after acute brain ischemia also plays an important role in response to ischemic injury, preventing secondary infarct growth by counteracting the production of proinflammatory cytokines and by modulating the activation of lymphocytes and microglia. Immunomodulatory therapy seems promising in certain subgroups of patients with ischemic stroke. By now there are modest data on the benefit of this therapy, collected from small populations, further studies which will help us select these subgroups being needed.
URI: https://stiinta.usmf.md/ro/manifestari-stiintifice/zilele-universitatii
http://repository.usmf.md/handle/20.500.12710/13164
Appears in Collections:Culegere de postere

Files in This Item:
File Description SizeFormat 
59_160_235.pdf293.7 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback