Морфофункциональная характеристика кортикостероцитов коры надпочечных желез крыс при разных сроках алкоголизации

Abstract

Abstract Background: Adrenal glands are one of the most important elements of the regulatory system of the human body and the various exogenous and endogenous effects lead to a disruption of the structural and functional characteristics of this organ. Chronic alcohol consumption leads to violations of the complex regulatory systems of humans and animals, and questions the influence of alcohol on the adrenal glands, in spite of the long history of studying the problem of chronic alcohol intoxication until now been sanctified enough. Material and methods: Were studied adrenal glands of 96 male rats exposed to various terms of alcohol intoxication. Results: Identified changes that characterize the quantitative characteristics of the cells of different areas of the adrenal cortex, are in close function depending of the parameters reflecting their protein-synthetic activity. It is found that the dynamics of the size of the nucleus and the cytoplasm as well as the width of the zones of the adrenal cortex changes depending on the timing of alcoholization, which is accompanied by phase changes histochemical markers of proteinsynthetic activity of cells. Conclusions: Chronic alcohol consumption causes marked changes in the morphofunctional state of the cortex of the adrenal glands, which are caused by structural and metabolic changes in the cells of the adrenal cortex.