Aspecte structurale ale stromei din prostata normală

Abstract

Abstract The prostate is an organ extensively studied in recent years, particularly related to the prostate cancer. In fact, cancer is not just a disorder caused by uncontrolled cell growth. Malignancy also includes loss of normal tissue architecture, genetic changes and stromal changes. The human prostate is composed of two compartments: epithelial part (secretory acini and ducts) and stroma. Prostatic stroma has a complex structure and consists of two basic components: specific cellular component and the extracellular matrix. Each component has importance in the induction process and maintaining of local homeostasis that could contribute to malignant or benign transformation processes. In this review, we will focus our attention on studying of stromal microenvironment in normal conditions.