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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/15881
Title: Adhesive diseases in children. Prevention, diagnosis and treatment strategies
Authors: Bernic, Jana
Baranov, Lilia
Bernic, Valentin
Gudumac, Eva
Keywords: children;adhesive disease;diagnosis;treatment
Issue Date: 2021
Publisher: The Scientific Medical Association of the Republic of Moldova
Citation: BERNIC, Jana, BARANOV, Lilia, BERNIC, Valentin, GUDUMAC, Eva. Adhesive diseases in children. Prevention, diagnosis and treatment strategies. In: The Moldovan Medical Journal. 2021, vol. 64, no 1, pp. 10-21. ISSN 2537-6381. DOI: 10.5281/zenodo.4527032
Abstract: Abstract: Background: The adhesive disease and its associated complications, caused by adhesive mechanical bowel obstructions, mainly related to genetic causes and disorders of cell homeostasis are one of the major health problems due to their diverse impact on the growing organism. Material and methods: The clinical study was conducted on a group of 50 children aged 1 month – 18 years old with abdominal adhesion disorders, complicated by a bowel obstruction, following surgical intervention. Apart from the assessment of the anamnesis, clinical, and imaging manifestations, traditional bio-humoral homeostatic imbalance markers, endotoxemia levels, associated complications, and comorbidities, the blood inflammatory and excessive fibrosis biomarkers were assessed at different clinical periods of the pathological process. Results: A non-randomized pro- and retrospective study was carried out to assess the epidemiological, clinical and paraclinical, histopathological, evolutionary, preventive, and treatment characteristics in order to determine the major complication triggers following a surgical intervention on the small intestine, colon, appendix, or uterus, as well as to highlight their possible peculiarities in children. Conclusions: This study completed the clinicians’ views on intraperitoneal adhesion pathophysiology, thus confirming the importance of the microbial factor, inflammatory mediators, activation of humoral systems due to organic cellular lesions, the extension of the inflammatory response, as well as the genetic factors depending on the acetylation phenotype in children.
metadata.dc.relation.ispartof: The Moldovan Medical Journal
URI: http://moldmedjournal.md/wp-content/uploads/2021/02/64-1-Mold-Med-Journal-version-3.pdf
http://repository.usmf.md/handle/20.500.12710/15881
ISSN: 2537-6381
2537-6373
Appears in Collections:The Moldovan Medical Journal, Vol. 64, No 1, March 2021



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