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- IRMS - Nicolae Testemitanu SUMPh
- REVISTE MEDICALE NEINSTITUČšIONALE
- The Moldovan Medical Journal
- The Moldovan Medical Journal
- The Moldovan Medical Journal 2021
- The Moldovan Medical Journal, Vol. 64, No 1, March 2021
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/16038
Title: | Stem-cell therapies in critical limb ischemia |
Authors: | Visnevschii, Sergiu Malcova, Tatiana Calistru, Anatol Nacu, Viorel |
Keywords: | hypoxia;critical limb ischemia;peripheral arterial disease;transplantation;stem-cell therapy;tissue repair;angiogenesis |
Issue Date: | 2021 |
Publisher: | The Scientific Medical Association of the Republic of Moldova |
Citation: | VISNEVSCHII, Sergiu, MALCOVA, Tatiana, CALISTRU, Anatol, NACU, Viorel. Stem-cell therapies in critical limb ischemia. In: The Moldovan Medical Journal. 2021, vol. 64, no 1, pp. 63-67. ISSN 2537-6381. DOI: 10.5281/zenodo.4527192 |
Abstract: | Abstract.
Background: Due to stimulation of muscular regeneration in ischemic extremities and increasing blood flow, stem cells are considered a promising
new strategy for patients with critical limb ischemia (CLI). So, it is demonstrated that mesenchymal stem cells (MSCs), mononuclear cells derived from
bone marrow, peripheral and umbilical blood, adipose tissue encourage the genesis of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs).
By application of stem cell-based therapy, the following results are obtained: increased rate of ulcer healing, increased ankle-brachial index (ABI), and
transdermal oxygen pressure (TcPO2), improved revascularization, and reduced rate of amputation surgery. So, stem cell-based therapy demonstrates
good clinical outcomes. However, some adverse events related to cell sampling and mobilizations are reported. In addition, because of poor cell survival
in the condition of ischemia their therapeutic efficacy remains low which indicates further researchers are necessary for this field.
Conclusions: Cell-based therapy is a promising approach in CLI treatment. Its promising results have been already shown in smaller studies; however,
large-scale studies are entailed to ascertain their definitive role in anti-ischemic therapy. |
metadata.dc.relation.ispartof: | The Moldovan Medical Journal |
URI: | http://moldmedjournal.md/wp-content/uploads/2021/03/64-1-0-MMJ-vers-3-martie.pdf http://repository.usmf.md/handle/20.500.12710/16038 |
ISSN: | 2537-6381 2537-6373 |
Appears in Collections: | The Moldovan Medical Journal, Vol. 64, No 1, March 2021
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