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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/16038
Title: Stem-cell therapies in critical limb ischemia
Authors: Visnevschii, Sergiu
Malcova, Tatiana
Calistru, Anatol
Nacu, Viorel
Keywords: hypoxia;critical limb ischemia;peripheral arterial disease;transplantation;stem-cell therapy;tissue repair;angiogenesis
Issue Date: 2021
Publisher: The Scientific Medical Association of the Republic of Moldova
Citation: VISNEVSCHII, Sergiu, MALCOVA, Tatiana, CALISTRU, Anatol, NACU, Viorel. Stem-cell therapies in critical limb ischemia. In: The Moldovan Medical Journal. 2021, vol. 64, no 1, pp. 63-67. ISSN 2537-6381. DOI: 10.5281/zenodo.4527192
Abstract: Abstract. Background: Due to stimulation of muscular regeneration in ischemic extremities and increasing blood flow, stem cells are considered a promising new strategy for patients with critical limb ischemia (CLI). So, it is demonstrated that mesenchymal stem cells (MSCs), mononuclear cells derived from bone marrow, peripheral and umbilical blood, adipose tissue encourage the genesis of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs). By application of stem cell-based therapy, the following results are obtained: increased rate of ulcer healing, increased ankle-brachial index (ABI), and transdermal oxygen pressure (TcPO2), improved revascularization, and reduced rate of amputation surgery. So, stem cell-based therapy demonstrates good clinical outcomes. However, some adverse events related to cell sampling and mobilizations are reported. In addition, because of poor cell survival in the condition of ischemia their therapeutic efficacy remains low which indicates further researchers are necessary for this field. Conclusions: Cell-based therapy is a promising approach in CLI treatment. Its promising results have been already shown in smaller studies; however, large-scale studies are entailed to ascertain their definitive role in anti-ischemic therapy.
metadata.dc.relation.ispartof: The Moldovan Medical Journal
URI: http://moldmedjournal.md/wp-content/uploads/2021/03/64-1-0-MMJ-vers-3-martie.pdf
http://repository.usmf.md/handle/20.500.12710/16038
ISSN: 2537-6381
2537-6373
Appears in Collections:The Moldovan Medical Journal, Vol. 64, No 1, March 2021

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