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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/16039
Title: Predictive molecular markers of resistance to chemotherapy in breast cancer
Authors: Cucieru, Valerian
Keywords: breast cancer;neoadjuvant chemotherapy;biomarker;predictor
Issue Date: 2021
Publisher: The Scientific Medical Association of the Republic of Moldova
Citation: CUCIERU, Valerian. Predictive molecular markers of resistance to chemotherapy in breast cancer. In: The Moldovan Medical Journal. 2021, vol. 64, no 1, pp. 68-70. ISSN 2537-6381. DOI: 10.5281/zenodo.4527217
Abstract: Abstract. Background: Breast cancer is one of the three most common cancers along with lung and colon cancer. It is a leading cause of cancer deaths in both developing and developed countries. Within 2 decades, neoadjuvant chemotherapy (NAC) has become a standard treatment option in breast cancer. Relevant articles were identified by means of PubMed, Embase, Web of Science, Cochrane Library, and Springer Link databases published during the years 2010-2019, describing the role of molecular biomarkers in the assessment of NAC for breast cancer. Conclusions: The size of the breast primary tumor, the affection of the regional lymph nodes, the degree of tumor differentiation, the expression of hormone receptors, HER2neu, ki67 serve as the main criteria for predicting the response to NAC. Preoperative core needle biopsy is the gold standard procedure in cancer diagnostics, in the analysis of predictive biomarkers, particularly utilizing histomorphological characteristics. Carrying out a larger number of cycles of NAC as well as correlating the schemes in relation to the immunohistochemical types have a direct influence on obtaining a good response to treatment. Patients with a pathological complete response had superior survival outcomes compared with patients who had residual disease.
metadata.dc.relation.ispartof: The Moldovan Medical Journal
URI: http://moldmedjournal.md/wp-content/uploads/2021/03/64-1-0-MMJ-vers-3-martie.pdf
http://repository.usmf.md/handle/20.500.12710/16039
ISSN: 2537-6381
2537-6373
Appears in Collections:The Moldovan Medical Journal, Vol. 64, No 1, March 2021



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