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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/1848
Title: Optimizarea formulării comprimatelor orodispersabile cu maleat de clorfeniramină
Other Titles: Optimization of the formulation orodispersable tablets of chlorpheniramine maleate
Authors: Baroud, Allaa M. Fathi
Diug, Octavian
Diug, Eugen
Issue Date: 2011
Publisher: CEP Medicina
Citation: BAROUD, Allaa M. Fathi, DIUG, Octavian, DIUG, Eugen. Optimizarea formulării comprimatelor orodispersabile cu maleat de clorfeniramină. In: Anale ştiinţifice ale USMF “Nicolae Testemiţanu”. Ed. a 12-a. Chişinau: СEP Medicina, 2011, vol. 1: Probleme medico-biologice şi farmaceutice, pp.393-398.
Abstract: The purpose of this research was to develop mouth dissolve tablets of Chlorpheniramine maleate. Tablets were prepared by direct compression. The tablets were evaluated for disintegration time and hardness test. In the investigation, a 32 full factorial design was used to investigate the joint influence of 2 formulation variables: amount of Croscarmellose sodium and Lactose. The results of multiple linear regression analysis revealed that for obtaining of a rapidly disintegration dosage form, tablets should be prepared using an optimum concentration of Lactose and higher percentage of Croscarmellose sodium. Au fost cercetate comprimatele orodispersabile cu maleat de clorfeniramină, preparate prin comprimare directă. A fost evaluat timpul de dezagregare şi rezistenţa mecanică. Pentru optimizarea formulării a fost folosit designul factorial deplin randomizat 32 . Croscarmeloza sodică şi lactoza au fost selectate ca variabile independente. În rezultatul analizei multiple regresionale a fost relevat raportul optimal al cantităţilor de croscarmeloză şi lactoză care permit obţinerea valorilor scontate ale timpului de dezagregare şi al rezistenţei mecanice a comprimatelor cu dezagregare rapidă.
URI: http://repository.usmf.md/handle/20.500.12710/1848
Appears in Collections:Chimie generală și farmaceutică. Tehnologia medicamentelor

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