|
- IRMS - Nicolae Testemitanu SUMPh
- 1. COLECȚIA INSTITUȚIONALĂ
- MATERIALE ALE CONFERINȚELOR ȘTIINȚIFICE
- Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 2021
- Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 20-22 octombrie 2021: Culegere de postere
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/19150
Title: | The role and mechanisms of action of microRNAs in cancer |
Authors: | Corjan, Valentina Sardari, Veronica |
Keywords: | microRNAs;cancer;miRNA expression;epigenetic changes;biomarkers |
Issue Date: | 2021 |
Publisher: | Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova |
Citation: | CORJAN, Valentina, SARDARI, Veronica. The role and mechanisms of action of microRNAs in cancer: [poster]. In: Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 20-22 octombrie 2021: culegere de postere. 2021, p.19. |
Abstract: | Introduction
MicroRNAs (miRNAs) are a family of small non-coding RNAs that
function in post-transcriptional gene regulation, act as tumor suppressors
or oncogenes in different types of cancer. The dysregulated miRNAs
have been shown to affect the hallmarks of cancer, including sustaining
proliferative signaling, evading growth suppressors, resisting cell death,
activating invasion and metastasis, and inducing angiogenesis. The purpose
To highlight various mechanisms of dysregulation of miRNA expression
and their role in formation and development of human cancer. Material and methods
Various databases (miRCancer, OncomiR, miRactDB, miRbase, miRDB)
have been studied to highlight the mechanisms of miRNA dysregulation
in cancer and 23 scientific articles have been analyzed. Results
Abnormal miRNA expression in malignant cells has been often attributed to
alterations in genomic microRNA copy numbers and gene locations (deletion or
translocation) and dysregulation of some key transcription factors, such as cMyc and p53. Similarly, the epigenetic alterations were elucidated in the
context of their association with cancer, including global genomic DNA
hypomethylation, aberrant DNA hypermethylation of tumor suppressor genes
and disruption of the histone modification patterns. Conclusions
In malignant cells, miRNAs are heavily dysregulated by multiple mechanisms,
including deletion or translocation of miRNA genes, abnormal transcriptional
control, epigenetic changes that can be used as useful biomarkers for cancer
diagnosis and prognosis. |
metadata.dc.relation.ispartof: | Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 20-22 octombrie 2021 |
URI: | http://repository.usmf.md/handle/20.500.12710/19150 |
Appears in Collections: | Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 20-22 octombrie 2021: Culegere de postere
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|