Transient global amnesia as a possible manifestation after COVID-19 infection. Clinical cases

Abstract

Introduction: Since the beginning of the COVID-19 pandemic, an increasing number of patients with Transient Global Amnesia (TGA) was attested in neurological emergency departments [1,2]. However, there is limited data on the mechanism of TGA linked with COVID-19, in the convalescence period. Purpose: To analyze the possible linkage between SARS-CoV-2 infection and TGA in two patients, during the convalescence state. Material and methods: 2 clinical cases of TGA, manifested during the convalescence period of the COVID19 infection. Results Case no. 1 A 62-year-old man, that suffered a mild form of COVID-19 infection in February 2021, he presented an episode of TGA within one month. Brain MRI was normal.

Case no. 2 A 68-year-old man with TGA, 4 months after a severe COVID-19 pneumonia. Fronto-temporal, bilateral, cerebral atrophy was established on brain MRI. Conclusions: Novel coronavirus may be implicated in possible pathophysiological mechanisms, involving the frontal and temporal lobes, which might trigger TGA. Further studies are required.