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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/21734
Title: Low-grade systemic inflammation in subclinical hypothyroidism
Authors: Vudu, Stela
Krishna, Gouri Durga
Keywords: subclinical hypothyroidism;low-grade inflammation;levothyroxine treatment
Issue Date: 2022
Publisher: The Scientific Medical Association of the Republic of Moldova
Abstract: Background: Hypothyroidism is the deficiency in the production of thyroid hormones to meet the requirements of peripheral tissues. Subclinical hypothyroidism (SCH) is defined biochemically as normal serum free thyroxin concentration in the presence of an elevated serum thyroid-stimulating hormone (TSH) concentration. SCH may be associated with low-grade systemic inflammation (increased high sensitivity-C reactive protein (hs-CRP), one possible explanation may be that TSH in adipocytes promotes the release of interleukin-6 (IL-6). Studies have confirmed inflammatory biomarkers like hs-CRP and IL-6 to be a predictor of cardiovascular (CV) events. However, the treatment of SCH remains subject to debate. Conclusions: It is increasingly evident that SCH has prognostic values and crucial clinical effects, which leads to the view of SCH not being a compensated biochemical change sensu strictu. Even a modest but consistent fluctuation in the circulating thyroid hormone levels can create a response from the human heart. Well-timed treatment should be considered as a precaution to avoid the unfavourable CV diseases. The inflammatory biomarkers, namely CRP and IL-6 are exceptionally robust markers of cardiovascular risk. Thus, using these biomarkers may be helpful in assessing the cardiovascular risk in patients with subclinical hypothyroidism.
metadata.dc.relation.ispartof: The Moldovan Medical Journal
URI: https://doi.org/10.52418/moldovan-med-j.65-1.22.09
https://moldmedjournal.md/wp-content/uploads/2022/08/Mold-Med-Journal-2022-Vol-65-No-1-Vers-5.pdf
http://repository.usmf.md/handle/20.500.12710/21734
ISSN: 2537-6373
2537-6381
Appears in Collections:The Moldovan Medical Journal. Vol. 65, No 1, August 2022

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