- IRMS - Nicolae Testemitanu SUMPh
- REVISTE MEDICALE NEINSTITUČšIONALE
- The Moldovan Medical Journal
- The Moldovan Medical Journal
- The Moldovan Medical Journal 2022
- The Moldovan Medical Journal. Vol. 65, No 1, August 2022
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/21734
Title: | Low-grade systemic inflammation in subclinical hypothyroidism |
Authors: | Vudu, Stela Krishna, Gouri Durga |
Keywords: | subclinical hypothyroidism;low-grade inflammation;levothyroxine treatment |
Issue Date: | 2022 |
Publisher: | The Scientific Medical Association of the Republic of Moldova |
Abstract: | Background: Hypothyroidism is the deficiency in the production of thyroid hormones to meet the requirements of peripheral tissues. Subclinical
hypothyroidism (SCH) is defined biochemically as normal serum free thyroxin concentration in the presence of an elevated serum thyroid-stimulating
hormone (TSH) concentration. SCH may be associated with low-grade systemic inflammation (increased high sensitivity-C reactive protein (hs-CRP),
one possible explanation may be that TSH in adipocytes promotes the release of interleukin-6 (IL-6). Studies have confirmed inflammatory biomarkers
like hs-CRP and IL-6 to be a predictor of cardiovascular (CV) events. However, the treatment of SCH remains subject to debate.
Conclusions: It is increasingly evident that SCH has prognostic values and crucial clinical effects, which leads to the view of SCH not being a compensated
biochemical change sensu strictu. Even a modest but consistent fluctuation in the circulating thyroid hormone levels can create a response from the
human heart. Well-timed treatment should be considered as a precaution to avoid the unfavourable CV diseases. The inflammatory biomarkers, namely
CRP and IL-6 are exceptionally robust markers of cardiovascular risk. Thus, using these biomarkers may be helpful in assessing the cardiovascular risk
in patients with subclinical hypothyroidism. |
metadata.dc.relation.ispartof: | The Moldovan Medical Journal |
URI: | https://doi.org/10.52418/moldovan-med-j.65-1.22.09 https://moldmedjournal.md/wp-content/uploads/2022/08/Mold-Med-Journal-2022-Vol-65-No-1-Vers-5.pdf http://repository.usmf.md/handle/20.500.12710/21734 |
ISSN: | 2537-6373 2537-6381 |
Appears in Collections: | The Moldovan Medical Journal. Vol. 65, No 1, August 2022
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