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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/24169
Title: Assessment of the role of hematological inflammatory markers in the severity of intrahepatic cholestasis of pregnancy
Authors: Cemortan, Maria
Cernetchi, Olga
Keywords: pregnancy;childbirth;intrahepatic cholestasis of pregnancy;hematological inflammatory markers
Issue Date: 2022
Publisher: Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova
Citation: CEMORTAN, Maria, CERNETCHI, Olga. Assessment of the role of hematological inflammatory markers in the severity of intrahepatic cholestasis of pregnancy. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2022, vol. 28(2), pp. 19-24. ISSN 2345-1467.https://doi.org/10.52645/MJHS.2022.2.03
Abstract: Abstract Introduction. Hematological inflammatory markers may be promising diagnostic markers for assessing the severity of intrahepatic cholestasis of pregnancy. The aim of the study was to evaluate and compare the levels of hematological inflammatory markers in intrahepatic cholestasis of pregnancy. Material and methods. A prospective cohort study of 142 clinical cases, divided into two groups depending on the presence of cholestasis gravidarum, was carried out. The research was conducted by assessing the level of bile acids and hematological inflammatory markers in the mother’s blood, as well as by studying medical records. The IBM Statistics SPSS 21 program was used to process the statistical data. To compare categorical variables, the χ² without the Yates’ continuity correction test was applied. Results. There was an increase in platelet-to-lymphocyte ratio in pregnant women with intrahepatic cholestasis of pregnancy compared to the control group (146.0±6.8 versus 135.2±7.3, respectively). The values of neutrophil-to-lymphocyte ratio and the average volume of platelets were similar in both groups. At the same time, the study found a decrease in the values of erythrocyte distribution among women whose pregnancy was complicated by cholestasis gravidarum. Conclusions. The study showed a significant increase in platelet-to-lymphocyte ratio in women whose pregnancy was complicated by cholestasis gravidarum, as well as an increase in this indicator with increasing levels of bile acids. Thus, this ratio may be a promising diagnostic marker in assessing the severity of intrahepatic cholestasis of pregnancy.
metadata.dc.relation.ispartof: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences
URI: https://cercetare.usmf.md/sites/default/files/inline-files/MJHS_28_2_2022.pdf
https://doi.org/10.52645/MJHS.2022.2.03
http://repository.usmf.md/handle/20.500.12710/24169
ISSN: 2345-1467
Appears in Collections:Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2022 nr. 2(28)



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