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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/24261
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dc.contributor.authorHaim, Lital-
dc.contributor.authorSidorenko, Ludmila-
dc.date.accessioned2023-05-10T09:48:41Z-
dc.date.available2023-05-10T09:48:41Z-
dc.date.issued2023-
dc.identifier.isbn978-9975-82-313-5-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/24261-
dc.description.abstractIntroduction. The COVID-19 pandemic and the mRNA vaccines that were developed for it catapulted the topic of mRNA vaccines to the forefront and brought them to the attention of the scientific community and the general public. Hundreds of millions of people have received the COVID-19 mRNA vaccine and they were considered a great success. Objective of the study. Providing an overview of the articles available on mRNA vaccines, a description of the method of its development, its mechanism of action, its applications and to discuss of the benefits and limitations of the vaccine. Material and Methods. This is a systematic review study. The databases PubMed and Google Scholar were searched for studies reporting on mRNA vaccine elaboration, mechanism of action, and applications by searching keywords. Studies that were peer-reviewed, and were published in platforms with higher impact factors were preferred. Also were included relevant publications in the time period of 2012-2023. Results. The mRNA vaccine development includes- the isolation of a pathogenic genetic material, synthesis of mRNA using a template, mRNA purification, and addition of a delivery system. mRNA vaccine mechanism of action involves the introduction of the vaccine to a recipient, mRNA uptake by targeted cells, mRNA-mediated protein expression, and immunogenicity development. Potential applications of the vaccine are as a protein replacement therapy, cancer immunotherapy, vaccines against various pathogens, and treatment of autoimmune diseases and allergies. The benefits of the technique are-rapid production which is useful in emerging infections, high efficacy, high adaptability to different antigen designs, possible titration, and high safety profile. Challenges and limitations of mRNA vaccines include the requirement of colder conditions in comparison to traditional vaccines, there is need of understanding the role of adjuvant addition to the vaccine, and the formulation of a vaccine in case of rapidly changing targeted antigens (breakthrough infections and immune escapes of cancers). Conclusion. mRNA vaccine technology has many benefits over traditional vaccines, which makes them a good possible alternative. These vaccines have various potential applications in different fields of medicine, further research should be performed in order to integrate them in the future in clinical practice.en_US
dc.language.isoenen_US
dc.publisherCEP Medicinaen_US
dc.relation.ispartof„Cells and tissues transplantation. Actualities and perspectives” dedicated to the 10th anniversary of the founding of the Human Tissue and Cells Bank and to the 15th anniversary of the founding of the Laboratory of Tissue Engineering and Cells Culture of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova, March 17-18th 2023, Chisinau, Republic of Moldovaen_US
dc.subjectvaccineen_US
dc.subjectmRNAen_US
dc.subjectCOVID-19en_US
dc.subjectpandemicen_US
dc.subjectelaborationen_US
dc.subjectmechanism of actionen_US
dc.subjectapplicationsen_US
dc.titlePrinciples of elaboration and usage of mRNA-based vaccinesen_US
dc.typeOtheren_US
Appears in Collections:The Materials of the National Scientific Conference with International Participation „Cells and tissues transplantation. Actualities and perspectives”

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