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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/26356
Title: Harmfulness of prooxidants in bronchopulmonary dysplasia in preterm children
Authors: Ceahlău, Mariana
Selevestru, Rodica
Tagadiuc, Olga
Șciuca, Svetlana
Keywords: bronchopulmonary dysplasia;preterm children;total prooxidant activity;prooxidant-antioxidant balance;malonic dialdehyde;nitric oxide metabolites
Issue Date: 2023
Publisher: Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova
Citation: CEAHLĂU, Mariana, SELEVESTRU, Rodica, TAGADIUC, Olga, ȘCIUCA, Svetlana. Harmfulness of prooxidants in bronchopulmonary dysplasia in preterm children. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2023, vol. 10(3), pp. 3-10. ISSN 2345-1467. https://doi.org/10.52645/MJHS.2023.3.01
Abstract: Abstract. Introduction. Oxidative stress can be defined as the imbalance of the redox state of a certain system including living one (organelle, cell, organ/tissue), which excessively produces reactive oxygen and/or reactive nitrogen species (ROS/RNS) that exceed the capacity of the antioxidant defense system, which have the ability to slow down or even prevent the oxidative damage of macromolecules. Oxidative stress is a pathogenic mechanism of a large variety of diseases, including pulmonary one. Material and methods. 81 preterm born children included in the study were divided into the main group – preterm children with bronchopulmonary dysplasia (BPD), and the control group – preterm children without BPD. The comparison groups were prospectively evaluated clinical, instrumental and laboratory (TPA, prooxidant-antioxidant balance, nitric oxide metabolistes and MDA). Data were statistically analyzed using Microsoft Excel, MedCalc and SPSS and Contingency Table Analysis as a way to evaluate the performance of a diagnostic test. Results. In preterm children with BPD were found to be decreased by 29% (p < 0.001) the prooxidant-antioxidant balance (PAB) and the nitric oxide metabolistes (NO) level by 12% (p < 0.001) compared to children in the control group. The assessment of tissue oxidative damage markers revealed a significant 62% (p < 0.001) increase in malonic dialdehyde (MDA) content and a 4.86-fold (p < 0.001) increase in total prooxidant activity (TPA) in children with bronchopulmonary dysplasia compared to children in the control group. Our study confirms that TPA, PAB, MDA and NO values are reliable markers of hypoxic tissue damage at children with bronchopulmonary dysplasia and can be recommended for assessing the intensity of oxidative stress. Conclusions. Pulmonary bronchodysplasia is characterized by the imbalance of prooxidant-antioxidant processes with the exacerbation of prooxidant ones that trigger the oxidative/nitrosative stress and the deterioration of vital chemical compounds.
metadata.dc.relation.ispartof: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences
URI: https://cercetare.usmf.md/sites/default/files/inline-files/MJHS_10_3_2023.pdf
http://repository.usmf.md/handle/20.500.12710/26356
https://doi.org/10.52645/MJHS.2023.3.01
ISSN: 2345-1467
Appears in Collections:Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2023 nr. 3(10)

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