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- IRMS - Nicolae Testemitanu SUMPh
- 1. COLECȚIA INSTITUȚIONALĂ
- Revista de Științe ale Sănătății din Moldova
- Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2023 nr. 3(10)
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/26364
Title: | Venous and arterial endothelium: markers of dysfunction and pathophysiological significance |
Authors: | Ojog, Victor Lozovanu, Svetlana |
Keywords: | venous and arterial endothelium;markers of endothelial dysfunction |
Issue Date: | 2023 |
Publisher: | Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova |
Citation: | OJOG, Victor, LOZOVANU, Svetlana. Venous and arterial endothelium: markers of dysfunction and pathophysiological significance. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2023, vol. 10(3), pp. 43-52. ISSN 2345-1467. https://doi.org/10.52645/MJHS.2023.3.06 |
Abstract: | Abstract. Introduction. Endothelial dysfunction is a result of complex pathogenic interface involving inflammation, oxidative stress,
disorders of endothelization and hemostasis etc., in both arteries and veins, leading to a lot of cardiovascular diseases.
Identifying markers with high predictive value has an important diagnostic and prognostic significance.
Material and methods. To create this review article, we conducted a thorough search for relevant references that are
current, specific, and aligned with the goals of the article. We utilized databases such as PubMed, MEDLINE, Google
Scholar, and Cochrane, going as far back as the year 2000 to gather the necessary information. The identified articles were
structured based on the main objectives, comprehensively analyzed, and the key findings have been critically exposed.
Results. A few main markers endothelial dysfunction were revealed, which reflect axial pathogenic events such as
inflammation, endothelium lesion and reendothelization, inherent hemostasis disorders and prothrombotic risk. Likewise,
some distinct morphophysiological traits of arterial and venous endothelium are disentangled, as well as markers having
common and distinct predictive power of endothelial dysfunction in arteries and veins.
Conclusions. Multi-marker panel is a reliable tool for prediction of endothelial dysfunction in both arteries and veins, as
well as the risk of inherent consequences. Noteworthy, majority of markers are common for arteries and veins, but some,
like C-reactive protein and von Willebrand factor should be treated distinctly. |
metadata.dc.relation.ispartof: | Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences |
URI: | https://cercetare.usmf.md/sites/default/files/inline-files/MJHS_10_3_2023.pdf https://doi.org/10.52645/MJHS.2023.3.06 http://repository.usmf.md/handle/20.500.12710/26364 |
ISSN: | 2345-1467 |
Appears in Collections: | Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2023 nr. 3(10)
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