- IRMS - Nicolae Testemitanu SUMPh
- 1. COLECȚIA INSTITUȚIONALĂ
- Revista de Științe ale Sănătății din Moldova
- Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2023 nr. 4(10)
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http://hdl.handle.net/20.500.12710/26647
Title: | Humoral immune status in patients with parasitic arthritis |
Authors: | Grosu, Maia Groppa, Liliana Plăcintă, Gheorghe |
Keywords: | parasitic arthritis;immunoglobulins;Echinococcus;Giardia Lamblia;Toxocara Canis |
Issue Date: | 2023 |
Publisher: | Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova |
Citation: | GROSU, Maia, GROPPA, Liliana, PLĂCINTĂ, Gheorghe. Humoral immune status in patients with parasitic arthritis. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2023, vol. 10, nr. 4, pp. 19-23. ISSN 2345-1467. DOI: https://doi.org/10.52645/MJHS.2023.4.03 |
Abstract: | Introduction. The description of clinical manifestations of parasitic infestation includes joint damage manifested by arthralgia and arthritis, however, until today; the form of joint damage in parasitic infections is not clinically defined. The
multitude of parasites creates a heterogeneous joint involvement, and the intensifying of specific manifestations would be
an important premise in clinical diagnosis.
Objective. Assessment of immunological changes in the context of parasitosis and their ratio depending on the clinical
variant of parasitic arthritis.
Material and methods. A group of 161 patients with parasitic arthritis was selected, established in two stages of compliance according to specific and serological criteria. The average age was 47.0±2.1 years, 72 men / 89 women. The average
duration of joint syndrome was 50.4±15.6 months. The first group (97 patients) had parasitic arthritis of echinococcosis
infestation, the 2nd (31 patients) – parasitic arthritis of Toxocara cannis and the 3rd (33 patients) had parasitic arthritis of
Giardia lamblia infestation.
Results and discussion. IgA was increased above normal in all patients with parasitic arthritis (4.25±0.001; p < 0.001).
IgM showed significant changes, depended on infestation agent (p < 0.05). Patients with normal IgG levels predominated,
except for patients from the group with echinococcosis parasitic arthritis (p > 0.05). The amount of IgE exceeds normal
values in Echinococcus parasitic arthritis (38.40 ng/ml), Toxocara canis (34.16 ng/ml), Giardia lamblia (45.06 ng/ml).
Conclusions. This suggests that the key aspects of immunity against parasites are mainly determined by the size of the
harmful organisms that the immune system needs to combat. Macroorganism includes unique defense mechanisms that
can be effective against multicellular helminths: high production of IgA and IgE and activation of key effector cells – eosinophils. |
metadata.dc.relation.ispartof: | Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences |
URI: | https://cercetare.usmf.md/sites/default/files/inline-files/Maia%20Grosu%2C%20Liliana%20Groppa%2C%20Gheorghe%20Pl%C4%83cint%C4%83%20Humoral%20immune%20status%20in%20patients%20with%20parasitic%20arthritis.pdf https://doi.org/10.52645/MJHS.2023.4.03 http://repository.usmf.md/handle/20.500.12710/26647 |
ISSN: | 2345-1467 |
Appears in Collections: | Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2023 nr. 4(10)
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