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- IRMS - Nicolae Testemitanu SUMPh
- 1. COLECȚIA INSTITUȚIONALĂ
- Revista de Științe ale Sănătății din Moldova
- Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2024 nr. 1(11)
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/27092
Title: | Manifestations of kidney involvement in COVID-19 patients and progression to chronic kidney disease |
Authors: | Răzlog, Tatiana Russu, Eugeniu Alexa, Zinaida Ceban, Emil Groza, Costina Groppa, Liliana |
Keywords: | chronic kidney disease;acute kidney injury;COVID-19 |
Issue Date: | 2024 |
Publisher: | Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova |
Citation: | RĂZLOG, Tatiana, RUSSU, Eugeniu, ALEXA, Zinaida, et al. Manifestations of kidney involvement in COVID-19 patients and progression to chronic kidney disease. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2024, nr. 1(11), pp. 11-18. ISSN 2345-1467. https://doi.org/10.52645/MJHS.2024.1.02 |
Abstract: | Introduction. COVID-19 was initially considered a predominantly respiratory infection, with mortality associated with
progression of respiratory failure, but currently is recognized as a multisystem disease with a wide range of manifestations. One of the most common complications of COVID-19 is acute kidney injury (AKI), which predominantly evolved to
chronic kidney disease (CKD). The objective of the study was to investigate the types of acute kidney injury and their prognostic value in hospitalized patients with COVID-19 with evolution to chronic kidney disease.
Material and methods. The study utilized a comprehensive database of patients admitted to general department of
COVID-19 at Timofei Moșneaga Republican Clinical Hospital from 2020 to 2022 years (in total 1000 patients). The first part
of the study was a retrospective study, focusing on patients with confirmed COVID-19 and lung injury was diagnosed by
computer tomography. The second part was a prospective study assessing the prognostic value of inflammatory markers,
renal functional status and kidney injury.
Results. AKI occurs in 29.6% of patients with COVID-19. The risk of AKI and CKD is higher in patients with more comorbidities, a more severe course of disease, elevated levels of ASAT/ALAT > 1.6 and hematuria at admission, which significantly
increases the risk of progression to CKD. Patients with a history of CKD, and who had ASAT > 40 U/L, ASAT/ALAT > 1.6 and
hematuria, experience the onset of AKI before hospitalization. Independent negative predictors of hospital-developed AKI
include hypertension, Charlson Comorbidity Index > 4 points, respiratory failure, ASAT/ALAT > 1.6, D-dimers > 250 ng/ml,
and hematuria. Hospital mortality in patients with COVID-19 was 20.8%, compared to 8.5% in patients without AKI, and
this rate increased to 50% when AKI developed (p < 0.001).
Conclusions. Patients who developed AKI during admission had a higher incidence of negative outcomes compared to
those with AKI prior to admission. Independent predictors of in-hospital mortality in COVID-19 patients were increased
serum CRP. Death in hospitalized patients with COVID-19 and AKI was independently associated with factors such as age >
75 years, history of CKD, admission to Intensive Care Unit, leukocytosis, and ASAT/ALAT > 1.6. |
metadata.dc.relation.ispartof: | Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences |
URI: | https://doi.org/10.52645/MJHS.2024.1.02 https://cercetare.usmf.md/sites/default/files/inline-files/Tatiana%20R%C4%83zlog%2C%20Eugeniu%20Russu%2C%20Zinaida%20Alexa%2C%20Emil%20Ceban%2C%20Costina%20Groza%2C%20Liliana%20Groppa%20Manifestations%20of%20kidney%20involvement%20in%20COVID-19%20patients%20and%20progression%20to%20chronic%20kidney.pdf http://repository.usmf.md/handle/20.500.12710/27092 |
ISSN: | 2345-1467 |
Appears in Collections: | Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2024 nr. 1(11)
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