Long-term consequences of the impact of post-COVID syndrome on chronic pathology

Abstract

Introduction. In Ukraine, the coronavirus infection Covid-19 (new type of pneumonia) was diagnosed for the first time on March 3, 2020 in Chernivtsi, and on March 13, the first fatal case was recorded. Material and methods. An analysis of available scientific sources (224) on the molecular pathophysiology of COVID-19 showed that the biomedical terms associated with C0VID-19/SARS-CoV-2 form several clusters: cluster 1 - is inflammation and the formation of a cytokine storm; cluster 2 - pathophysiological rationale for the treatment of coronavirus infection; cluster 3 - comorbid conditions and post-covid syndrome. The aim of the study. To assess the separate consequences of the impact of the post-covid syndrome on the course and formation of chronic pathology. The results. Long-COVID is a multi-system, multi-organ disease: more than 200 post-covid symptoms have been identified in 10 organ systems. The long-COVID-19 masks have a single multifactorial pathogenesis of complications - pathophysiological syndromes: endothelitis, systemic inflammation, damage to the nervous system, damage to the respiratory system (pneumonitis), pronounced asthenic syndrome. Conclusions. 1. The expression of post-covid symptoms was significantly higher in patients who had a severe form of the disease and were treated under an intensive care program. 2. Polysyndromic symptoms also occurred in young people who survived the disease without complications. 3. Questions remain open regarding the long-term impact of infection on the human body, whether it provokes the appearance of other new diseases, how it affects physical endurance, how the functioning of our organs and systems changes.