Ros-induced mitochondriopathies and their redox bioregulation through low-dose medical ozone

Abstract

Introduction. Low-dose ozone acts as redox bioregulator in chronic inflammatory diseases with high oxidative stress. Objective. The restoration of a disturbed redox balance was demonstrated in rheumatoid arthritis, osteoarthritis, diabetes, and prevention. Material and methods. Preclinical studies in rats versus clinical studies with measurement of the relevant parameters on the oxidative stress side, such as malondialdehyde, and antioxidant markers on the repair side of the redox balance, such as glutathione or superoxide dismutase. Results. In both preclinical and clinical studies, the redox balance improved statistically significantly. Conclusions. In mitochondriopathies ozone showed good results as an adjunct in complementary treatment systems.