The study of mechanisms of anti-inflammatory activity realization of a new malonic acid derivative – maldian

Abstract

Background: The aim of this work was to study the implementation mechanisms established earlier, the anti-inflammatory activity of a new compound – di-(2,4-dimethyl) malonic acid anilide, code name – “Maldian”. Material and methods: The study was performed on nonlinear white male rats, weighing 220-250 g. The implementation mechanisms of maldian pharmacological action studied in terms of the effect of a new substance on the level of prostaglandin E and the effect on the activity of proteolytic enzymes of the kinin system in the blood of intact animals on the background of carragenine edema. Maldian antioxidant activity was assessed by the impact on the processes of lipid peroxidation in the membranes of liver mitochondria in rats. The role of adrenal system showing maldian anti-inflammatory effect was also studied. Results: It is found that maldian at a dose of 7.3 mg/kg has a pronounced antioxidant activity reducing free radicals oxidation processes. There is an ability to inhibit kininogens, to inhibit the activity of the leading mediator of inflammation – kallikrein in the mechanism of anti-inflammatory maldian activity. Maldian significantly decreases the level of prostaglandin E on the background of acute inflammatory reaction. Anti-inflammatory maldian activity is implemented without any effects on the adrenal cortex. Conclusions: Considering the results obtained, maldian – (di-(2,4-dimethyl) anilide malonic acid, is a promising compound for further pharmacological study and introduction into medical practice as a new modern drug with anti-inflammatory action.