Surveillance of quinolone generations in Emergency Medicine Institute

Abstract

Background: The main goal of the study was to evaluate the institutional representative data on quinolones antibacterial generations in accordance with WHO requirements, to determine the value of Defined Daily Doses per 1000 Occupied-Bed Days (DDD/1000) and cost in most important departments, comparing it with the same published data of international scientific journals. Material and methods: For this study we used the data of a six-year (2009-2014) period in the Emergency Medicine Institute and their subdivisions with main consumption of antibiotics which shows the consumption dynamics of quinolone generations use in grams and value indexes. Results: In the evaluated period, the medium yearly consumption of all quinolone generations recorded 63.03 DDD/1000 or a share of 11.14% from medium annual total of 566.02 DDD/1000 antibiotics. The same data in other international hospitals recorded 71.24 or 11.84% from total of 601.36 DDD/1000. In the end of the evaluated period, in IC departaments, the consumption of the first and the second generations registered 112.13 DDD/1000 and respectively the third and the fourth 6.02 DDD/1000 or a decrease by 2.27 and 13.85 times. In SSOT departments in the end of the evaluation the first and the second generations recorded 57.59 DDD/1000 or an increase by 40.25%. Medium annual cost per DDD/1000 for the first and the second generations of quinolone antibacterials in ICD recorded 4731.78 lei, the third and the fourth generations 6526.15 lei and respectively in SSOTD 365.78 lei and 149.20 lei. Conclusions: In the end of the evaluated period in ICD of EMI quinolones of the first and the second generations represent 94.90% and the third and the fourth generations 5.10% from the total consumption. In SSOTD departments and in the entire EMI, the third and the fourth generations represent less than 1% of all consumption. This evaluation, as a part of multidisciplinary approach, serves as an important point for further survey of protocols and guides concerning the antibiotic consumption in one hospital.