Evaluation of Tetracyclines and Aminoglycosides consumption

Abstract

Background: Tetracyclines and Aminoglycosides antimicrobials hold the last positions among all main antibiotic subgroups used yearly in hospitals. Nevertheless,without these medical remedies a qualified treatment of patients with different illnesses cannot be well organized or even would be impossible. Material and methods: For this study we used data of a six-year (2009-2014) period, in the Emergency Medicine Institute and their subdivisions where happened main consumption of antibiotics such as: Reanimation, Therapeutic intensive care, Therapeutic "stroke” intensive care, septic Surgery and septic Orthopedic-Traumatology departments - which show the consumption dynamics of Tetracyclines and Aminoglycosides antimicrobials use in grams and value indexes. Results: The defined daily doses (DDD) per 1000 occupied-bed days (DDD/1000) in Emergency Medicine Institute in 2009 and 2014 for Tetracyclines registered an increase from 8.2 to 20.8 or a share of 1.24% and 4.48% from the total annual consumption. Aminoglycosides recorded a decrease from 83.1 to 43.7 that represents a share of 12.55% and 9.42% from the total annual consumption. The same data in Intensive care departments recorded for Tetracyclines an increase from 3.61 to 53.98 DDD/1000 or 0.27% and 4.48% and respectively for Aminoglycosides from 494.49 to 134.4 or 15.12% and 11.16%. Septic departments recorded from 3.56 to 17.63 DDD/1000 or 0.57% and 3.44% and respectively for Aminoglycosides from 142.83 to 137.04DDD/1000 or 22.64% and 26.77%. In the mentioned period medium consumption in international hospitals of Tetracycline’s increased from 27.00 to 70.00 DDD/1000 or by 2.59 times, and comparatively with the EMI in 2014 was higher by 3.36 times. Aminoglycosides consumption in international hospitals decreased from 50.00 to 40.00 DDD/1000 or by 20% and in 2014 year was similar with the data recorded in EMI. Cost of DDD/1000 in Emergency Medicine Institute during 2009 and 2014 years, for Tetracyclines registered 1.89 and 5.57 lei, for Aminoglycosides respectively 461.19 and 460.83 lei. In Intensive care departments costs recorded 0.98 and 14.44 lei and 2793.61 and 2634.39 lei, and in Septic departments 0.4 and 4.75 lei and 536.61 and 329.23 lei respectively. Conclusions: We found an increase in consumption of Tetracyclines DDD/1000 during the evaluated period, at the same time consumption in international hospitals in 2014 was in medium 70.00 DDD/1000 or 3.36 times more than 20.8 DDD/1000 recorded in EMI. Aminoglycosides in the evaluated period decreased in DDD/1000 consumption in EMI and international hospitals and in 2014 was around the same.