- IRMS - Nicolae Testemitanu SUMPh
- 1. COLECȚIA INSTITUȚIONALĂ
- Revista de Științe ale Sănătății din Moldova
- Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2024 Vol. 11, Issue 4
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http://hdl.handle.net/20.500.12710/30077
Title: | Mechanisms of niacin skin test pathogenesis in patients at clinical high risk for psychosis and schizophrenia |
Authors: | Nastas, Igor Boronin, Larisa |
Keywords: | niacin;skin test;pathogenesis;psychotic disorders;high-risk populations;schizophrenia |
Issue Date: | 2024 |
Publisher: | Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova |
Citation: | NASTAS, Igor; BORONIN, Larisa. Mechanisms of niacin skin test pathogenesis in patients at clinical high risk for psychosis and schizophrenia. In: Revista de Ştiinţe ale Sănătăţii din Moldova = Moldovan Journal of Health Sciences. 2024, vol. 11, nr. 4, pp. 54-61. ISSN 2345-1467. DOI: https://doi.org/10.52645/MJHS.2024.4.09 |
Abstract: | Introduction. Elevated or imbalanced levels of markers of oxidative stress and inflammation are often observed in various
somatic pathologies and mental disorders, including schizophrenia.
Purpose of the study. This study aims to investigate the mechanisms of pathogenesis and the evidence supporting the use
of niacin skin and oral tests in patients with schizophrenia.
Materials and methods. A literature review was conducted on the specific reactions to the niacin skin or oral test in patients with schizophrenia, first-episode psychosis, and those at clinical high risk for psychosis (CHR-P). Evidence-based
data up to and including 2024 were reviewed, with 48 literary sources selected.
Results. An attenuated niacin-induced flush, coupled with low vitamin B3 levels, an imbalance in the Redox-Ratio and
omega-3/omega-6 fatty acids, and elevated phospholipase A2 levels, are the main evidence-based findings associated with
schizophrenia.
Conclusions. The niacin skin and oral tests in patients with schizophrenia and those at high risk for psychosis are characterized by an abnormal response to niacin. Additional markers may further validate positive test results for niacin. |
metadata.dc.relation.ispartof: | Revista de Ştiinţe ale Sănătăţii din Moldova = Moldovan Journal of Health Sciences |
URI: | https://doi.org/10.52645/MJHS.2024.4.09 https://mjhs.md/sites/default/files/2024-12/MJHS_11_4_2024.pdf http://repository.usmf.md/handle/20.500.12710/30077 |
ISSN: | 2345-1467 |
Appears in Collections: | Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2024 Vol. 11, Issue 4
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