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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/30095
Title: Acute autoimmune hemolytic anemia in a patient with systemic lupus erythematosus
Authors: Chirca, Vera
Popa, Serghei
Agachi, Svetlana
Dutca, Lucia
Corotaș, Valeriu
Keywords: systemic lupus erythematosus;autoimmune hemolytic anemia;antinuclear antibodies;ANA;Anti-dsDNA;Anti-phospholipid;corticosteroids;immunosuppressants;cyclophosphamide
Issue Date: 2024
Publisher: Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova
Citation: CHIRCA, Vera; POPA, Serghei; AGACHI, Svetlana; DUTCA, Lucia; COROTAȘ, Valeriu. Acute autoimmune hemolytic anemia in a patient with systemic lupus erythematosus. In: Revista de Ştiinţe ale Sănătăţii din Moldova = Moldovan Journal of Health Sciences. 2024, vol. 11, nr. 3, pp. 59-64. ISSN 2345-1467. DOI: https://doi.org/10.52645/MJHS.2024.3.09
Abstract: Introduction. Autoimmune hemolytic anemia occurs due to the accelerated destruction of erythrocytes as a result of the dysfunction of immune system cells, which produce antibodies against the normal antigens of the membrane of hematopoietic cells. One of its causes is systemic lupus erythematosus. Materials and methods. We present a case of a 20-year-old patient who was hospitalized with acute autoimmune hemolytic anemia, having been diagnosed with SLE at the age of 18 years. At the onset of the disease, hemolytic anemia was a differential diagnostic challenge. Results. The differential diagnosis between primary and secondary autoimmune hemolytic anemia (AIHA) was an important step. The presence of antinuclear antibodies (ANA Hep2, Anti-dsDNA, Anti-cardiolipin, Anti-phospholipids, anti-Ro, Anti-Sm B) were important arguments in making the diagnosis. The relapse of AIHA was caused by inadequate treatment, due to a lack of compliance. Pulse therapy combined with methylprednisolone and cyclophosphamide successfully resolved the AIHA. Conclusions. Hematological abnormalities are commonly seen in SLE patients, but hemolytic autoimmune anemia is a rare condition. A timely diagnosis of the cause of hemolytic anemia and proper treatment of lupus by correcting autoimmune disorders are crucial in disease management. Pulse therapy combined with corticosteroids and immunosuppressants is effective in acute relapses of hemolytic anemia.
URI: https://mjhs.md/journal/september-2024
https://doi.org/10.52645/MJHS.2024.3.09
http://repository.usmf.md/handle/20.500.12710/30095
ISSN: 2345-1467
Appears in Collections:Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2024 Vol. 11, Issue 3

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