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- IRMS - Nicolae Testemitanu SUMPh
- 1. COLECȚIA INSTITUȚIONALĂ
- MATERIALE ALE CONFERINȚELOR ȘTIINȚIFICE
- „Cells and tissues transplantation. Actualities and perspectives. The 3rd edition” dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025
- The Materials of the National Scientific Conference with International Participation „Cells and tissues transplantation. Actualities and perspectives. The 3rd edition” dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025: [Abstracts]
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/30392
Title: | Why is “brainwashing” necessary? Histophysiology investigation |
Authors: | Crețu, Maxim Șaptefrați, Lilian |
Keywords: | glymphatic system;AQP4;neuroinflammation;astrocytes;CSF;perivascular space |
Issue Date: | 2025 |
Publisher: | CEP Medicina |
Citation: | CREȚU, Maxim and Lilian ȘAPTEFRAȚI. Why is “brainwashing” necessary? Histophysiology investigation. In: Cells and tissues transplantation. Actualities and perspectives. The 3rd edition : The Materials of the National Scientific Conference with international participation dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025: [abstracts]. Chişinău: CEP Medicina, 2025, p. 85. ISBN 978-9975-82-413-2. |
Abstract: | Background. The glymphatic system represents the indispensable mechanism for maintaining
cerebral homeostasis, facilitating the drainage of cerebrospinal fluid (CSF) and the direct evacuation
of neurotoxic metabolites. Thus, understanding the fundamental mechanisms of this system is
essential for advancing neurobiology and implementing innovative, potentially revolutionary
treatments for the prevention of neurodegenerative diseases.
Objective of the study. To analyze and investigate, from a histological and physiological point of
view, the structure and functions of the glymphatic system, emphasizing the relevance of
"brainwashing" for supporting neuronal integrity and preventing progressive neurological diseases.
Material and methods. There have been reviewed the specialized literature published between 2012
and 2024 was reviewed, integrating information obtained in the PubMed, Springer Link,
ScienceDirect databases, regarding the structure, physiology and functions of the glymphatic system
and the correlation of its dysfunctions with the development of neurodegenerative dysfunctions.
Results. It has been demonstrated that CSF drainage through the glymphatic system is an active
process, dependent on arterial pulsations and the activity of astrocytes and AQP4 channels. It is
found that the fluid flow increases significantly during deep sleep, with a share of over 60%, which
allows for an efficient elimination of metabolic waste, and in the long term would represent a
protective factor in neurodegenerative diseases. Also, recent studies on neurotransmitters have
highlighted the importance of norepinephrine in modulating the activity of the glymphatic system,
through its periodic release during sleep, respectively determining the pulsations of the vessels and
facilitating the circulation of CSF and the clearance of the brain, these discoveries emphasize the
close link between the quality of sleep and the efficiency of neuronal detoxification processes.
Conclusion. The glymphatic system proves to be a key element in protecting neurological health,
ensuring the continuous elimination of metabolic residues and maintaining an optimal environment
for neuronal functioning. This research offers new opportunities for the development of innovative
therapeutic strategies for the prevention and treatment of neurodegenerative diseases, thus
transforming the concept of "brainwashing" into a fundamental physiological process for the
maintenance of long-term cognitive functions. |
metadata.dc.relation.ispartof: | Cells and tissues transplantation. Actualities and perspectives. The 3-rd edition. Chisinau, March 21-22, 2025 |
URI: | https://repository.usmf.md/handle/20.500.12710/30392 |
ISBN: | 978-9975-82-413-2 |
Appears in Collections: | The Materials of the National Scientific Conference with International Participation „Cells and tissues transplantation. Actualities and perspectives. The 3rd edition” dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025: [Abstracts]
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