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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/3066
Title: Contribuţii la optimizarea algoritmilor de prelucrare a informaţiei cromatografice (comunicarea 2)
Other Titles: The contributions in optimisation of the chromatographic information handling algorithms
Authors: Casian, Igor
Casian, Ana
Valica, Vladimir
Keywords: HPLC;Data Handling;Chromatographic Peaks Deconvolution
Issue Date: 2005
Publisher: Revista Farmaceutică a Moldovei
Abstract: Rezumat. Lucrarea este dedicată studiului metodelor matematice pentru separarea picurilor cromatografice parţial suprapuse: scăderea sectorului cromatogramei de fond, modelarea cromatogramelor cu utilizarea funcţiilor algebrice şi de aparat. S-au discutat avantajele şi dezavantajele fiecărei metode, propunîndu-se propriile recomandări la optimizarea algoritmilor de calcul corespunzători. S-au selectat două modele algebrice – Gauss exponenţial modificat şi Asimetric bisigmoidal, care descriu mai adecvat picurile reale, aparente în HPLC. Experimental, s-au evaluat erorile analizei cantitative a cromatogramelor în funcţie de gradul de suprapunere a picurilor şi nivelului de zgomot la utilizarea modelelor algebrice şi de aparat. This paper is dedicated to research of mathematical methods for separation of particular overlapped chromatographic peaks: subtraction of sectors of background chromatogram, modelling of chromatograms using apparatus and algebraic functions. Surveyed of advantage and disadvantages of each method, the own recommendations on optimisation of the corresponding computing algorithms are given. Two algebraic models – Exponentially Modified Gaussian and Asymmetric Double Sigmoid – most adequately describing real peaks apparent in HPLC have been selected. The experimental estimation of chromatograms quantification errors depending of various peaks overlapping and noise level is carried out at usage of apparatus and algebraic models.
URI: http://repository.usmf.md/handle/20.500.12710/3066
ISSN: 1812-5077
Appears in Collections:ARTICOLE ȘTIINȚIFICE



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