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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/30989
Title: Conventional and non-conventional risk factors for peripheral arterial disease in women
Authors: Spinei, Igor
Lubaș, Dragoș-Alexandru
Casian, Dumitru
Keywords: peripheral arterial disease;risk factors;reproductive history;women
Issue Date: 2025
Publisher: Asociaţia chirurgilor “Nicolae Anestiadi” din Republica Moldova
Citation: SPINEI, Igor; Dragoș-Alexandru LUBAȘ și Dumitru CASIAN. Conventional and non-conventional risk factors for peripheral arterial disease in women. Arta Medica. 2025, nr. 1(94), pp. 25-30. ISSN 1810-1852. DOI: 10.5281/zenodo.15880359
Abstract: Summary. Objectives. To conduct a scoping review of the scientific literature summarizing current knowledge regarding gender-related differences in conventional and the impact of non-conventional risk factors for peripheral arterial disease (PAD) in women. Methods. A comprehensive literature search was performed across PubMed, MEDLINE, SCOPUS and Google Scholar databases examining the risk factors for PAD. After initial identification of the most relevant articles, forward and backward citation tracking was performed for selection of additional publications. Finally, a total of 49 publications (45 original articles, 2 systematic reviews and 2 clinical practice guidelines) were included and analysed. Results. Conventional factors for the development and progression of PAD have several sex-specific features in women: more significant impact of smoking and diabetes, less effective correction of dyslipidemia and hypertension, frequent association with obesity and osteoporosis. Furthermore, current evidence highlights the importance of non-conventional risk factors for PAD in females: sex-hormones disbalance, reproductive history and adverse obstetric events. Conclusions. There are numerous gender-related peculiarities in the natural evolution of PAD in female patients which may influence the clinical presentation, diagnosis and outcomes of medical and interventional treatment. Further studies are required for a better understanding of sex-related vulnerability mechanisms and elaboration of individualized management.
metadata.dc.relation.ispartof: Arta Medica
URI: DOI: 10.5281/zenodo.15880359
https://artamedica.md/index.php/artamedica/issue/view/31/32
https://repository.usmf.md/handle/20.500.12710/30989
ISSN: 1810-1852
Appears in Collections:Arta Medica Nr. 1(94) 2025

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