Interacţiunea alcool-tiamină: calea biochimică spre encefalopatia Wernicke

Abstract

Introducere. Consumul cronic de alcool are un efect neurotoxic major asupra sistemului nervos central, conducând la tulburări cognitive, motorii şi comportamentale. Tulburările neurologice alcool-induse reflectă modificări complexe la nivel molecular şi structural, cu repercusiuni neurofuncţio-nale semnificative. Scop. Studierea mecanismelor patobio-chimice asociate consumului cronic de alcool şi metabolismului tiaminei (B1) pentru elucidarea relaţiei cauzale dintre acestea şi apariţia encefalopatiei Wernicke (EW). Material şi metode. Studiul a inclus 10 articole ştiinţifice publicate în ultimii 10 ani, disponibile în acces deschis, selectate din bazele de date PubMed şi ScienceDirect.

Introduction. Chronic alcohol consumption has a major neurotoxic effect on the central nervous system, leading to cognitive, motor and behavioral disorders. Alcohol-induced neurological disorders reflect complex changes at the molecular and structural levels, with significant neurofunctional repercussions. Objective. The study of the patho-biochemical mechanisms associated with chronic alcohol consumption and thiamine (B1) metabolism to elucidate the causal relationship with Wernicke’s encephalopathy (WE). Material and methods. The study included 10 scientific articles published in the last 10 years, available in open access, selected from the PubMed and ScienceDirect databases.