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- IRMS - Nicolae Testemitanu SUMPh
- 1. COLECȚIA INSTITUȚIONALĂ
- Congresul consacrat aniversării a 80-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova
- Congresul consacrat aniversării a 80-a de la fondarea USMF „Nicolae Testemițanu”, 20-22 octombrie 2025: Abstract book
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/31940
| Title: | ASPECTE TERAPEUTICE ÎN NEFROPATIA DIABETICĂ |
| Other Titles: | THERAPEUTIC ASPECTS IN DIABETIC NEPHROPATHY |
| Authors: | Vellayikottu, Aswathi |
| Keywords: | like “diabetic nephropathy,” “renal fibrosis,” “SGLT2 inhibitors,” and “inflammatory cytokines in DN” guided the selection of 24 critically analyzed article. Results. Diabetic nephropathy (DN) is marked by increased cardiovascular risk;progressive decline in glomerular filtration rate;and persistent albuminuria. Its pathogenesis involves oxidative stress;glomerular hypertension;metabolic disturbances;and chronic inflammation. Key molecular drivers include hyperglycemia;advanced glycation end-products (AGEs);and profibrotic cytokines such as TGF-0. Diagnostics use biomarkers and advanced imaging for earlier detection. Treatments include SGLT2 inhibitors and GLP-1 receptor agonists. Future therapies target inflammation and fibrosis with endothelin receptor antagonists and monoclonal antibodies. Conclusion. Effective management of diabetic nephropathy requires understanding its pathogenesis alongside emerging therapies. Integrating molecular insights into clinical practice allows healthcare providers to tailor personalized interventions;slow disease progression;and improve patient outcomes |
| Issue Date: | 2025 |
| Publisher: | |
| Citation: | Vellayikottu, Aswathi. ASPECTE TERAPEUTICE ÎN NEFROPATIA DIABETICĂ = THERAPEUTIC ASPECTS IN DIABETIC NEPHROPATHY. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2025, vol. 12, Nr. 3/2025, anexa 2, p. 209. ISSN 2345-1467. |
| Abstract: | Introducere. Nefropatia diabetică (DN), o complicaţie mi-crovasculară complexă a diabetului zaharat, reprezintă una dintre principalele cauze ale bolii renale cronice şi ale insuficienţei renale în stadiu terminal la nivel global. Evoluţia sa progresivă a dus la cercetări şi terapii tot mai specifice şi eficiente. Scop. Revizuirea strategiilor terapeutice actuale şi emergente în nefropatia diabetică, cu accent pe conexiunea lor cu mecanismele moleculare şi inflamatorii implicate în progresia bolii. Material şi metode. Această analiză se bazează pe analiza calitativă a articolelor evaluate de colegi din PubMed, Google Scholar, Medline şi Science-Direct, publicate între 2015 şi 2024. Introduction. Diabetic nephropathy (DN), a complex mi-crovascular complication of diabetes mellitus, is a leading cause of chronic kidney disease and end-stage renal failure worldwide. Its progressive nature has led to extensive research into its mechanisms and to the development of more targeted, effective therapies. Objective. To review and analyze current and emerging therapeutic strategies for diabetic nephropathy, focusing on their connection to underlying molecular and inflammatory mechanisms of progression. Material and methods. This review is based on qualitative analysis of peer-reviewed articles from PubMed, Google Scholar, Medline, and ScienceDirect, published between 2015 and 2024. |
| metadata.dc.relation.ispartof: | Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences |
| URI: | https://cercetare.usmf.md/sites/default/files/2025-10/MJHS_12_2_2025_anexa2site.pdf https://repository.usmf.md/handle/20.500.12710/31940 |
| ISSN: | 2345-1467 |
| Appears in Collections: | Congresul consacrat aniversării a 80-a de la fondarea USMF „Nicolae Testemițanu”, 20-22 octombrie 2025: Abstract book
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