Community-acquired pneumonia in patients with chronic heart failure: Summary of the PhD thesis in medical sciences: 321.01 Internal Medicine (Pneumology)

Abstract

Structure of the thesis: the thesis is presented on 135 pages of basic text that includes an introduction, 4 chapters and conclusions. The work cites 305 bibliographic sources, being illustrated by 47 tables, 31 figures, 4 appendixes. The obtained results are published in 21 scientific papers. Key words: community-acquired pneumonia, heart failure, clinical-paraclinical features, oxidative stress. Field of study: 321.01 Internal diseases (with specification: Pulmonology). Aim of the study: assessment of clinical, paraclinical peculiarities, the disease course and oxidative stress characteristics in community-acquired pneumonia in patients with chronic heart failure. Study objectives: assessment of clinical, paraclinical peculiarities and the disease course in patients with community-acquired pneumonia and concomitant chronic heart failure; assessment of oxidative stress markers in patients with community-acquired pneumonia and chronic heart failure; correlation of inflammatory and oxidative stress indices with clinical and paraclinical data in patients with community-acquired pneumonia and chronic heart failure; determination of clinical, paraclinical peculiarities and the disease course in patients with community-acquired pneumonia and chronic heart failure, depending on the left ventricular ejection fraction and the functional class of heart failure; analysis of the diagnostic accuracy of communityacquired pneumonia severity scores (PSI/PORT, CURB-65, DS-CRB-65) and development of a model for predicting the severe progression of community-acquired pneumonia in chronic heart failure. Scientific novelty and originality: the clinical-paraclinical and evolutionary data of community-acquired pneumonia in patients with chronic heart failure were analyzed, the importance of inflammatory and oxidative stress markers in patients with community-acquired pneumonia and chronic heart failure was determined. The scientific problem solved in the thesis: the results of the study allowed the development of a model to predict the unfavorable outcome of community-acquired pneumonia in patients with pre-existing chronic heart failure. The theoretical significance and applied value of the work: the research into the clinical, paraclinical, and the disease course aspects of community-acquired pneumonia in chronic heart failure has enabled the development of practical recommendations for diagnostic management, both at the prehospital and hospital stages of care. Implementation of the scientific results: The practical recommendations are used in the General Therapy Department and the Pneumology Division of Municipal Clinical Hospital "Holy Trinity" and in the didactic process within the Discipline of Clinical Syntheses, Department of Internal Medicine of "Nicolae Testemițanu" State University of Medicine and Pharmacy.