Polipi ereditari adenomatosi colorectali la pacientii Rep. Moldova- aspecte genetice

Abstract

In the light of the progress achieved in the area of improving the methods of recombined DNA technology, today it has become possible to diagnose a genetic disease, including the Hereditary colorectal polyps as a form of epithelial colorectal neoplasia (ECRN) at the level of genes. To identify the clinical differences between patients with sporadic adenoma from the ones with hereditary neoplasm, genetico-molecular investigations were carried out on a group of patients diagnosed with ECRN. Identification of genetic associations between polymorphous spectra of DNA and the genetic expression was done using the RT-PCR technique.

Datorită progreselor înregistrate în perfectionarea metodelor tehnologiei ADN recombinat, astăzi este posibil diagnosticul unei boli genetice, inclusiv ale polipilor colorectali ereditari, ca formă de neoplazie epitelială colo-rectală(NECR), la nivelul genei. Un lot de pacienţi cu NECR a fost supus unor investigaţii genetico-moleculare, în scopul diferenţierii clinice dintre subiecţii cu adenomi sporadici de cei cu origine ereditară. Identificarea asocierilor genetice dintre spectrele polimorfe de ADN şi expresia genică s-a fost efectuat prin intermediul tehnicii RT-PCR.