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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/4712
Title: Unele efecte ale interacţiunii asocierii izoturon-propranolol cu oxigenul hiperbaric la nivelul metabolismului lipidic
Other Titles: Some effects of the izoturone and propranolol association interaction with hyperbaric oxygen on the lipidic metabolism level
Authors: Cheptea, Eduard
Gonciar, Veaceslav
Keywords: Izoturone
Issue Date: 2012
Publisher: CEP "Medicina"
Citation: CHEPTEA, Eduard, GONCIAR, Veaceslav. Unele efecte ale interacţiunii asocierii izoturon-propranolol cu oxigenul hiperbaric la nivelul metabolismului lipidic. In: Anale Științifice ale USMF “Nicolae Testemiţanu”. Ed. a 13-a. Chișinău: CEP Medicina, 2012, Vol. 1: Probleme medico-biologice şi farmaceutice, pp. 215-222.
Abstract: In the experiments on rats the effects of the izoturone and propranolol association interaction with hyperbaric oxygen (HBO) on the lipid metabolism level was studied. HBO (6 ata 50 min) caused the increase of plasmatic concentration of total lipids, total phospholipids, esterified cholesterol, total lipoproteins, α+γ-lipoproteins, β-lipoproteins and cholesterol of total lipoproteins and of their fractions. Association of the izoturone (20 mg/kg) and propranolol (1,5 mg/kg) in normobaric conditions provoked the decrease of the content of total lipids and the increase of concentration of total phospholipids, triglycerids, β-lipoproteins and cholesterol of β- lipoproteins. A complex metabolic interaction of the level of lipidic and lipoproteinic metabolism on the simultaneous prescription of izoturone and propranolol combination and HBO was revealed. In majority of cases the association of izoturone and propranolol and HBO reciprocally normalized the modification of parameters of lipidic metabolism, in some - pharmacological agents act similarly manifasting a tendency of effects accumulation. În experimente pe şobolani au fost studiate efectele interacţiunii asocierii izoturon şi propranolol cu oxigenul hiperbaric (OHB) la nivelul metabolismului lipidic. OHB (6 ata 50 min) a cauzat majorarea concentraţiei plasmatice de lipide totale, fosfolipide totale, colesterol esterificat, lipoproteine totale, α+γ-lipoproteine, β-lipoproteine şi colesterol al lipoproteinelor totale şi fracţiilor lor. Asocierea izoturonului (20 mg/kg) şi propranololului (1,5 mg/kg) în condiţii normobarice a micşorat conţinutul plasmatic de lipide totale şi majorarea concentraţiei de fosfolipide totale, trigliceride, β-lipoproteine şi colesterol al β-lipoproteinelor. La administrarea concomitentă a asocierii izoturonului şi propranololului cu OHB s-a observat o interacţiune complexă la nivelul metabolismului lipidic şi lipoproteic. În majoritatea cazurilor 216 combinaţia izoturonului cu propranololul şi OHB au normalizat reciproc modificările indicilor metabolismului lipidic, în unele – agenţii farmacologici acţionează similar, manifestând tendinţă de acumulare a efectelor.
URI: http://repository.usmf.md/handle/20.500.12710/4712
Appears in Collections:Farmacologie și farmacologie clinică

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