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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/7449
Title: Влияние натриевой соли 3-(2-оксо-3-фенил-2Н-[1,2,4]триазина[2,3-с] хиназолин-6-ил) пропановой кислоты и бемитила на биохимические процессы в организме крыс в условиях ежедневных тренировок в третбане
Other Titles: Effect of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]triazine[2,3-c] quinazolin-6-yl) propanoic acid and bemityl on biochemical processes in rats organism in the conditions of the daily training with running in treadmill
Authors: Saenko, A.V.
Zaichko, N.V.
Stepanyuk, G.I.
Keywords: propanoic acid;actoprotective action;MT-279;bemethyl;metabolic processes
Issue Date: 2014
Publisher: The Scientific Medical Association of the Republic of Moldova
Citation: SAENKO, A. V.; ZAICHKO, N. V.; STEPANYUK, G. I. Влияние натриевой соли 3-(2-оксо-3-фенил-2Н-[1,2,4]триазина[2,3-с] хиназолин-6-ил) пропановой кислоты и бемитила на биохимические процессы в организме крыс в условиях ежедневных тренировок в третбане. In: Curierul Medical. 2014, vol. 57, no 6, pp. 31-36. ISSN 1875-0666.
Abstract: Background: The limited arsenal of actoprotectors by almost one bemethyl has caused the necessity to search the substances with the above action, suitable for the creation of a new drug on their basis. Material and methods: For the investigation the substances of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]triazine[2,3-c]quinazolin-6-yl) propane acid with the laboratory ciphers MT-279 has been taken. The studies have been performed on 56 nonlinear male rats in the conditions of the 15-daily physical loading which promoted the normalization of energy processes in skeletal muscles (energy resources were increased, lactoacidosis was removed, the lipolysis was activated) and interaction within system «pro-and antioxidant». Results: It has been established that the course (15 days) intraperitoneal injections in rats with sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4] triazine[2,3-c]quinazolin-6-yl) propane acid (MT-279, 2.5 mg/kg), as well as bemethyl (33 mg/kg) promoted the normalization of energy processes in skeletal muscles (energy resources were increased, lactoacidosis was removed, the lipolysis was activated) and interaction within system «pro-and antioxidant». Conclusions: The compound MT-279 has the largest actoprotective effect virtually mapped to bemethyl. A complex of effects inherent of MT-279 compound indicates the advisability of the in-depth study of its pharmacological properties to find out its safety and suitability for creating a new drug on its basis.
metadata.dc.relation.ispartof: Curierul Medical
URI: http://repository.usmf.md/handle/20.500.12710/7449
http://moldmedjournal.md/wp-content/uploads/2016/09/Cm-6-2014-Electronic-version.pdf
ISSN: 1875-0666
Appears in Collections:Curierul Medical, 2014, Vol. 57, Nr. 6



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