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- IRMS - Nicolae Testemitanu SUMPh
- REVISTE MEDICALE NEINSTITUȚIONALE
- The Moldovan Medical Journal
- Curierul Medical 2009 - 2016
- Curierul Medical, 2014
- Curierul Medical, 2014, Vol. 57, Nr. 6
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/7449
Title: | Влияние натриевой соли 3-(2-оксо-3-фенил-2Н-[1,2,4]триазина[2,3-с] хиназолин-6-ил) пропановой кислоты и бемитила на биохимические процессы в организме крыс в условиях ежедневных тренировок в третбане |
Other Titles: | Effect of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]triazine[2,3-c] quinazolin-6-yl) propanoic acid and bemityl on biochemical processes in rats organism in the conditions of the daily training with running in treadmill |
Authors: | Saenko, A.V. Zaichko, N.V. Stepanyuk, G.I. |
Keywords: | propanoic acid;actoprotective action;MT-279;bemethyl;metabolic processes |
Issue Date: | 2014 |
Publisher: | The Scientific Medical Association of the Republic of Moldova |
Citation: | SAENKO, A. V.; ZAICHKO, N. V.; STEPANYUK, G. I. Влияние натриевой соли 3-(2-оксо-3-фенил-2Н-[1,2,4]триазина[2,3-с] хиназолин-6-ил) пропановой кислоты и бемитила на биохимические процессы в организме крыс в условиях ежедневных тренировок в третбане. In: Curierul Medical. 2014, vol. 57, no 6, pp. 31-36. ISSN 1875-0666. |
Abstract: | Background: The limited arsenal of actoprotectors by almost one bemethyl has caused the necessity to search the substances with the above action,
suitable for the creation of a new drug on their basis.
Material and methods: For the investigation the substances of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]triazine[2,3-c]quinazolin-6-yl) propane
acid with the laboratory ciphers MT-279 has been taken. The studies have been performed on 56 nonlinear male rats in the conditions of the 15-daily
physical loading which promoted the normalization of energy processes in skeletal muscles (energy resources were increased, lactoacidosis was removed,
the lipolysis was activated) and interaction within system «pro-and antioxidant».
Results: It has been established that the course (15 days) intraperitoneal injections in rats with sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]
triazine[2,3-c]quinazolin-6-yl) propane acid (MT-279, 2.5 mg/kg), as well as bemethyl (33 mg/kg) promoted the normalization of energy processes in skeletal
muscles (energy resources were increased, lactoacidosis was removed, the lipolysis was activated) and interaction within system «pro-and antioxidant».
Conclusions: The compound MT-279 has the largest actoprotective effect virtually mapped to bemethyl. A complex of effects inherent of MT-279
compound indicates the advisability of the in-depth study of its pharmacological properties to find out its safety and suitability for creating a new drug
on its basis. |
metadata.dc.relation.ispartof: | Curierul Medical |
URI: | http://repository.usmf.md/handle/20.500.12710/7449 http://moldmedjournal.md/wp-content/uploads/2016/09/Cm-6-2014-Electronic-version.pdf |
ISSN: | 1875-0666 |
Appears in Collections: | Curierul Medical, 2014, Vol. 57, Nr. 6
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