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- IRMS - Nicolae Testemitanu SUMPh
- REVISTE MEDICALE NEINSTITUȚIONALE
- The Moldovan Medical Journal
- Curierul Medical 2009 - 2016
- Curierul Medical, 2014
- Curierul Medical, 2014, Vol. 57, Nr. 6
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/7461
Title: | Rolul inflamaţiei sistemice în evoluţia afecţiunilor cardiovasculare |
Other Titles: | The role of systemic inflammation in cardiovascular disorders evolution |
Authors: | Panfile, E. |
Keywords: | systemic inflammation;cardiovascular disorders |
Issue Date: | 2014 |
Publisher: | The Scientific Medical Association of the Republic of Moldova |
Citation: | PANFILE, E. Rolul inflamaţiei sistemice în evoluţia afecţiunilor cardiovasculare. In: Curierul Medical. 2014, vol. 57, no 6, pp. 72-80. ISSN 1875-0666. |
Abstract: | Background: Growing clinic-experimental evidences suggest notable systemic inflammation implication in the pathogenesis of multiple cardiovascular
diseases. This article is aimed at underlying the most important referred to inflammation mechanisms causing circulatory disorders and proven predictors
of their diagnosis and prognosis. It has been established that crucial triggering factor of inflammatory response is the nuclear transcription factorkappaB whose activation leads to increased quantity and expression of a lot of inflammation mediators, like C reactive protein, cytokines (TNF-alpha,
interleukins), chemokines (MCP-1) and intercellular adhesion molecules (selectins, integrins) which basically guide the sequestration of circulatory
leukocytes. These mediators are responsible for inflammation sustaining and dissemination. On the other hand IL-10 is defined as a cytokine having
anti-inflammatory action. The common effects of inflammation are endothelial dysfunction associated with NO synthesis impairment, oxidative stress
boosting, extracellular matrix reorganization resulted from metalloproteinase activation, cell migration proliferation and apoptosis, neointima hyperplasia
and plaque destabilization.
Conclusions: Recent studies indicate the inflammation pathogenic value in the major adverse cardiovascular events development in patients
undergone primary coronary revascularization by angioplasty, inclusive in-stent restenosis. Diabetes mellitus, smoking, dislipidemia, metabolic syndrome,
hyperhomocysteinemia, arterial hypertension are main cardiovascular risk factors leading to inflammatory response augmentation. |
metadata.dc.relation.ispartof: | Curierul Medical |
URI: | http://repository.usmf.md/handle/20.500.12710/7461 http://moldmedjournal.md/wp-content/uploads/2016/09/Cm-6-2014-Electronic-version.pdf |
ISSN: | 1875-0666 |
Appears in Collections: | Curierul Medical, 2014, Vol. 57, Nr. 6
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