- IRMS - Nicolae Testemitanu SUMPh
- 5. FACULTATEA DE FARMACIE / FACULTY OF PHARMACY
- Catedra de chimie farmaceutică și toxicologică
- MATERIALE ALE CONFERINȚELOR
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/8274
Title: | THE EVALUATION OF SOME TECHNIQUES OF THERMAL ANALYSIS AT THE PREFORMULATION STAGE OF COMBINED DRUGS |
Authors: | Donici, Elena |
Issue Date: | May-2018 |
Publisher: | MedEspera 2018 The 7th International medical congress for students and young doctors, May 3-5, 2018, Chisinau, Republic of Moldova: Abstract book |
Abstract: | Introduction. Thermal analysis includes several analysis techniques, which measure an
analytical signal of the sample at a certain temperature. The analysis is based on
thermogravimetric curves. The instrument used in thermal analysis consists of a microbalance
surrounded by a electrically heated furnace equipped with a thermocouple to monitor the
temperature.
Aim of the study. is to assess the use of of thermo-gravimetric and differential scanning
calorimetry methods at the preformulation stage of combined drugs.
Materials and methods. Electronic databases: Medline, Cochrane, Embase and Springer. Also,
the search was conducted by using printed, pharmaceutical and chemical journals. It was
analyzed 150 bibliographic sources.
Results. In most of the researches (45%), thermogravimetric analysis was used in order to
determine the decomposition temperature of the individual active substances and also from the
mixtures of active substances with excipients or with other active substances. Also, most
frequently (53.3%), thermogravimetric analysis has been combined with other techniques such
as: differential scanning calorimetry. Less researches (1.7%) applied thermogravimetric method
to determine water content and volatile substances.
Conclusions. Thermogravimetry and differential scanning calorimetry are physicochemicalmethods which are widely used for compatibility research of active substances and
excipients at the preformulation stage of drugs. |
URI: | https://medespera.asr.md/wp-content/uploads/Abastract-Book-2018.pdf http://repository.usmf.md/handle/20.500.12710/8274 |
ISBN: | 978-9975-47-174-9 |
Appears in Collections: | MATERIALE ALE CONFERINȚELOR
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|