Biological stimulation of diabetic ulcers healing

Abstract

Introduction: Despite many studies, diabetes does not respond to radical treatment, and footulcers do not heal for a long time. Aim: The aim of our study was toevaluatethe reparatory effect of platelet-rich plasma (PRP) in the treatment of patients with diabetic foot in stage 2. Materials and methods: The study included 32 patients with diagnosis of diabetic foot in stage 2. At the time of inclusion in the study, all patients had a defect of the skin and subcutaneous fat on the foot, measuring 3-6 cm2 , which was not corrected by traditional methods for 3-4 months. All patients were divided in 2 groups: comparison group (n=18 (56.25%) – standard therapy; study group (n=14;43.75%) – standard therapy and local serial administration of PRP. The area of the ulcers was measured before manipulation, as well as at 1 week intervals until the ulcer was completely healed. Results: Our experience with PRP in the treatment of patients with diabetic foot in stage 2 demonstrated the effectiveness of this technique. A progressive, significant (p<0.01) decrease in the area of the ulcerative defect starting from the 14th day was noted. When using PRP, we managed to achieve complete healing of diabetic ulcers in 64.2% of patients on day 35 and in 100% of patients on day 42. Conclusion: Local administration of an PRP allows the complete healing of diabetic ulcers in stage 2 with an area of 3-6 cm2 for 6 weeks.