Abstract:
Background: Determination of the general immune status and the effectiveness of the complex treatment with local immunostimulation (autologous
mononuclear cells) of chronic rhinosinusitis in children.
Material and methods: The general immunity status and the effectiveness of the complex treatment with local immunostimulation were examined by
the application in the maxillary sinuses of activated autologous mononuclear cells in 19 children with chronic rhinosinusitis and 116 healthy children.
Results: The presence of allergic reactions by increase in IgE and CD4/CD8 index was determined in patients examined. The sensitization to streptococcal
antibodies was assessed by the cell sensitization data and the presence of streptococcal antibodies according to ASL-0 data. The inhibition of the T-cells
was functional decrease of T-lymphocytes in the TTBL test with phytohemagglutinin and tendency towards a decrease of the T-CD-3 lymphocytes titer.
The compensatory activation of the B-cells (increase in the IgA titer) was determined. The objective follow-up examination of the patients over one year
revealed the absence of hyperemia and edema of the nasal mucosa, while an insignificant nasal obstruction was present in 5 children. The rhinomanometric
examination demonstrated an increase in total volume indices and a decrease in the total nasal resistance in all treated children. The new method of local
immunocorrection of chronic rhinosinusitis in children proved to be clinically effective.
Conclusions: There were determined increased IgE, CD4 / CD-8 index and CIC (PEG-8% with low molecular weight), cellular sensitization to streptococcal
antibodies according to TTBL data, inhibition of the T-cells and tendency towards a decrease of T-CD-3 lymphocytes. Also, the compensatory activation
of the B-cells (increase in the IgA titer) was determined.
Description:
Department of Otorhinolaryngology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Department of Immunology and Allergy, Chiril Draganiuc Institute of Phtisiopulmonology, Chisinau, the Republic of Moldova