Abstract:
Background: Immune cells interact not only with tumor cells but also with stromal cells facilitating the progression of neoplasia. The ongoing battle
between immune cells and the tumor is an important factor influencing the clinical course and outcome of treatment in various types of cancer. The aim
of the study was to identify the prognostic value of dendritic cells and macrophages in prostate carcinoma.
Material and methods: This retrospective study analyzed 73 samples of prostate cancer. The macrophages and dendritic cells have been evaluated using
the immunohistochemical methods with CD68 (macrophages) and S100 (dendritic cells). Macrophages were quantified as intratumoral and peritumoral,
and dendritic cells – intraepithelial and stromal. The results were analyzed statistically.
Results: For evaluation of the prognostic impact of immune cells was accomplished a correlation between the total number of CD68+/S100+ cells and
the Gleason score. Thus, statistically significant correlations were obtained both for CD68+ cells (intratumoral p=0.008, peritumoral p=0.001), and for
S100+ cells (intraepithelial p=0.036, stromal p=0.042). In addition, a statistically significant positive linear correlation was observed between the density
of intraepithelial S100+ cells and intratumoral CD68+ cells (p=0.018).
Conclusions: The increase in the density of S100+ and CD68+ cells, as well as the significant association of their density with the histological degree of
the tumor allow us to consider these cells as predictive biomarkers in prostate carcinomas.
Description:
Department of Histology, Cytology and Embryology, Laboratory of Morphology, Department of Clinical Anatomy, Department of Biochemistry and Clinical Biochemistry
Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova, The 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020)
