Abstract:
Background: The pathogenesis theories of preeclampsia include inappropriate trophoblast invasion and incomplete remodeling of spiral uterine arteries.
This is followed by a reduced utero-placental perfusion; ischemia is the cause of oxidative stress activation. The imbalance between the oxidant and
antioxidant components in favor of pro-oxidation, induce endothelium activation and / or dysfunction with the occurrence of clinical and laboratory
manifestations.
Material and methods: It was proposed a comparative prospective study including 105 pregnant women with preeclampsia in comparison with 367
pregnancies without preeclampsia. Pro-oxidant and antioxidant status and its correlation with systolic blood pressure values and classical laboratory
marchers were analyzed.
Results: In preeclampsia there is an excess accumulation of pro-oxidants comparing to control group p<0.001. Malondialdehyde and Advanced Oxidation
Protein Products are most implicated in hypertensive syndrome r 0.7, p<0.001. Inflammatory diseases of uro-excretory tract accompanying preeclampsia,
demonstrate excess accumulation of Advanced Oxidation Protein Products and AGE verprelizine-like and AGE pentozidine-like r 0.7, p<0.001. Modified
ischemic albumin did not get the modified value in the research group.
Conclusions: Excess accumulation of pro-oxidants in preeclampsia plays an important role in pathogenesis pathway, clinical and laboratory manifestation
of preeclampsia.
Description:
Department of Obstetrics and Gynecology, Institute of Mother and Child, Chisinau, the Republic of Moldova
